Poor adherence to anti-seizure medications (ASMs) is associated with breakthrough
seizures and potentially increased toxicity in patients with epilepsy. Extended-release (ER) …

The amount of drug remaining after previous doses, or drug accumulation, is closely related
to drug efficacy and safety. An accurate calculation of the accumulation index or ratio (Rac) …

Delivering sparingly water-soluble drugs from ethylcellulose (EC) coated pellets with a
controlled-release pattern remains challenging. In the present study, hydrophilic …

Topiramate (TPM) was an antiepileptic agent commonly used in clinical. Studies showed
that an oral preparation of TPM with extended-release manner could bring some benefits for …

Purpose Although oral topiramate (TPM) products are widely prescribed for migraines and
epilepsy, injectable TPM is not available for human use. We have developed a solubilized …

Modified-release or extended-release (XR) formulations are used to decrease the frequency
of dosing for drugs with rapid elimination, to improve convenience and adherence. Use of a …

Objective For extended-release drugs with multi-compartment kinetics, such as topiramate,
effective half-life (t 1/2eff) may be a more clinically relevant parameter than elimination half …

Objective To evaluate the efficacy and safety of USL 255, Qudexy™ XR (topiramate)
extended‐release capsules, as an adjunctive treatment for refractory partial‐onset seizures …

Introduction Topiramate is a drug belonging to the second generation of antiseizure arsenal,
used to treat focal onset seizures without generalization, focal-to-bilateral tonic-clonic …

Purpose Compare the pharmacokinetic (PK) profiles of immediate‐and extended‐release
formulations of topiramate (TPM) in healthy subjects following multiple dosing, and evaluate …