A review of genome‐wide transcriptomics studies in Parkinson's disease
G Borrageiro, W Haylett, S Seedat… - European Journal of …, 2018 - Wiley Online Library
Parkinson's disease (PD) is a progressive and incurable neurodegenerative disorder.
Although numerous genetic and environmental factors have been linked to the aetiology of …
Although numerous genetic and environmental factors have been linked to the aetiology of …
[HTML][HTML] Proteins and transcriptional dysregulation of the brain extracellular matrix in Parkinson's disease: a systematic review
The extracellular matrix (ECM) of the brain is a dynamic structure made up of a vast network
of bioactive macromolecules that modulate cellular events. Structural, organizational, and …
of bioactive macromolecules that modulate cellular events. Structural, organizational, and …
An environment-dependent transcriptional network specifies human microglia identity
INTRODUCTION Microglia play essential roles in central nervous system homeostasis and
influence diverse aspects of neuronal function, including refinement of synaptic networks …
influence diverse aspects of neuronal function, including refinement of synaptic networks …
[HTML][HTML] Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson's disease
K Irmady, CR Hale, R Qadri, J Fak, S Simelane… - Nature …, 2023 - nature.com
The ability to use blood to predict the outcomes of Parkinson's disease, including disease
progression and cognitive and motor complications, would be of significant clinical value …
progression and cognitive and motor complications, would be of significant clinical value …
Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders
Y Chen, J Dai, L Tang, T Mikhailova, Q Liang, M Li… - Molecular …, 2023 - nature.com
Neuroinflammation has been implicated in multiple brain disorders but the extent and the
magnitude of change in immune-related genes (IRGs) across distinct brain disorders has not …
magnitude of change in immune-related genes (IRGs) across distinct brain disorders has not …
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons
F Zambon, M Cherubini, HJR Fernandes… - Human Molecular …, 2019 - academic.oup.com
Parkinson's disease (PD) is the second most common neurodegenerative disorder and a
central role for α-synuclein (αSyn; SNCA) in disease aetiology has been proposed based on …
central role for α-synuclein (αSyn; SNCA) in disease aetiology has been proposed based on …
[HTML][HTML] FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent …
Y Geng, X Long, Y Zhang, Y Wang, G You… - Journal of Translational …, 2023 - Springer
Background Parkinson's disease (PD), characterized by the progressive loss of
dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens …
dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens …
[HTML][HTML] Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration
Background Neuronal damage in acute CNS injuries and chronic neurodegenerative
diseases is invariably accompanied by an astrocyte reaction in both mice and humans …
diseases is invariably accompanied by an astrocyte reaction in both mice and humans …
Regional brain iron and gene expression provide insights into neurodegeneration in Parkinson's disease
The mechanisms responsible for the selective vulnerability of specific neuronal populations
in Parkinson's disease are poorly understood. Oxidative stress secondary to brain iron …
in Parkinson's disease are poorly understood. Oxidative stress secondary to brain iron …
[HTML][HTML] Integrative analyses of proteomics and RNA transcriptomics implicate mitochondrial processes, protein folding pathways and GWAS loci in Parkinson disease
A Dumitriu, J Golji, AT Labadorf, B Gao, TG Beach… - BMC medical …, 2015 - Springer
Background Parkinson disease (PD) is a neurodegenerative disease characterized by the
accumulation of alpha-synuclein (SNCA) and other proteins in aggregates termed “Lewy …
accumulation of alpha-synuclein (SNCA) and other proteins in aggregates termed “Lewy …