Parkinson's disease (PD) is a progressive and incurable neurodegenerative disorder.
Although numerous genetic and environmental factors have been linked to the aetiology of …

The extracellular matrix (ECM) of the brain is a dynamic structure made up of a vast network
of bioactive macromolecules that modulate cellular events. Structural, organizational, and …

INTRODUCTION Microglia play essential roles in central nervous system homeostasis and
influence diverse aspects of neuronal function, including refinement of synaptic networks …

The ability to use blood to predict the outcomes of Parkinson's disease, including disease
progression and cognitive and motor complications, would be of significant clinical value …

Neuroinflammation has been implicated in multiple brain disorders but the extent and the
magnitude of change in immune-related genes (IRGs) across distinct brain disorders has not …

Parkinson's disease (PD) is the second most common neurodegenerative disorder and a
central role for α-synuclein (αSyn; SNCA) in disease aetiology has been proposed based on …

Background Parkinson's disease (PD), characterized by the progressive loss of
dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens …

Background Neuronal damage in acute CNS injuries and chronic neurodegenerative
diseases is invariably accompanied by an astrocyte reaction in both mice and humans …

The mechanisms responsible for the selective vulnerability of specific neuronal populations
in Parkinson's disease are poorly understood. Oxidative stress secondary to brain iron …

Background Parkinson disease (PD) is a neurodegenerative disease characterized by the
accumulation of alpha-synuclein (SNCA) and other proteins in aggregates termed “Lewy …