Myocardial ischemia-reperfusion injury is an important cause of impaired heart function in
the early postoperative period subsequent to cardiac surgery. Reactive oxygen species …

Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary
cause of mortality worldwide in adults aged 35–70 years, occurring more often in countries …

There is substantial interest in the development of drugs that limit the extent of ischemia-
induced cardiac damage caused by myocardial infarction or by certain surgical procedures …

Reperfusion therapy must be applied as soon as possible to attenuate the ischemic insult of
acute myocardial infarction (AMI). However reperfusion is responsible for additional …

Heart failure is one of the leading causes of death and disability worldwide. Left ventricle
remodeling, fibrosis, and ischemia/reperfusion injury all contribute to the deterioration of …

Aims The present study was designed to examine the mechanism involved in mitochondrial
aldehyde dehydrogenase (ALDH2)-induced cardioprotection against ischaemia/reperfusion …

Hydroxy-2-nonenal (HNE) is one of the most studied products of phospholipid peroxidation,
owing to its reactivity and cytotoxicity. It can be formed by several radical-dependent …

A comprehensive focus on 4‐hydroxynonenal (HNE) as candidate molecule in a variety of
pathophysiological conditions occurring in humans is here provided. Despite an active, now …

Pharmacological conditioning aims to protect the heart from myocardial ischemia-
reperfusion injury (IRI). Despite extensive research in this area, today, a significant gap …

Mitochondria play a critical role in mediating the cellular response to oxidants formed during
acute and chronic cardiac dysfunction. It is widely assumed that, as cells are subjected to …