Type 2 diabetes mellitus and cardiovascular disease: genetic and epigenetic links

S De Rosa, B Arcidiacono, E Chiefari… - Frontiers in …, 2018 - frontiersin.org
Type 2 diabetes mellitus (DM) is a common metabolic disorder predisposing to diabetic
cardiomyopathy and atherosclerotic cardiovascular disease (CVD), which could lead to …

MicroRNAs and long non-coding RNAs in the pathophysiological processes of diabetic cardiomyopathy: emerging biomarkers and potential therapeutics

D Jakubik, A Fitas, C Eyileten, J Jarosz-Popek… - Cardiovascular …, 2021 - Springer
The epidemic of diabetes mellitus (DM) necessitates the development of novel therapeutic
and preventative strategies to attenuate complications of this debilitating disease. Diabetic …

HIF-1, metabolism, and diabetes in the embryonic and adult heart

R Cerychova, G Pavlinkova - Frontiers in Endocrinology, 2018 - frontiersin.org
The heart is able to metabolize any substrate, depending on its availability, to satisfy its
energy requirements. Under normal physiological conditions, about 95% of ATP is produced …

Diabetes and cardiovascular disease: inter-relation of risk factors and treatment

A Sharma, S Mittal, R Aggarwal… - Future Journal of …, 2020 - Springer
Background The diabetes mellitus prevalence is still advancing and increasingly becoming
one of the globally most severe and expensive chronic illnesses. The strong correlation …

The potential role of platelet-related microRNAs in the development of cardiovascular events in high-risk populations, including diabetic patients: a review

J Pordzik, K Pisarz, S De Rosa, AD Jones… - Frontiers in …, 2018 - frontiersin.org
Platelet activation plays a pivotal role in the development and progression of
atherosclerosis, which often leads to potentially fatal ischemic events at later stages of the …

Impact of sex differences and diabetes on coronary atherosclerosis and ischemic heart disease

R Madonna, CR Balistreri, S De Rosa… - Journal of clinical …, 2019 - mdpi.com
Cardiovascular diseases (CVD) including coronary artery disease (CAD) and ischemic heart
disease (IHD) are the main cause of mortality in industrialized countries. Although it is well …

Fibroblasts orchestrate cellular crosstalk in the heart through the ECM

SLK Bowers, Q Meng, JD Molkentin - Nature cardiovascular research, 2022 - nature.com
Cell communication is needed for organ function and stress responses, especially in the
heart. Cardiac fibroblasts, cardiomyocytes, immune cells and endothelial cells comprise the …

Epigenetic Modifications and Non-Coding RNA in Diabetes-Mellitus-Induced Coronary Artery Disease: Pathophysiological Link and New Therapeutic Frontiers

FR Prandi, D Lecis, F Illuminato, M Milite… - International Journal of …, 2022 - mdpi.com
Diabetes mellitus (DM) is a glucose metabolism disorder characterized by chronic
hyperglycemia resulting from a deficit of insulin production and/or action. DM affects more …

A literature embedding model for cardiovascular disease prediction using risk factors, symptoms, and genotype information

J Moon, HF Posada-Quintero, KH Chon - Expert Systems with Applications, 2023 - Elsevier
Accurate prediction of cardiovascular disease (CVD) requires multifaceted information
consisting of not only a patient's medical history, but genomic data, symptoms, lifestyle, and …

Diabetic cardiomyopathy: the role of microRNAs and long non-coding RNAs

MT Macvanin, Z Gluvic, J Radovanovic… - Frontiers in …, 2023 - frontiersin.org
Diabetes mellitus (DM) is on the rise, necessitating the development of novel therapeutic
and preventive strategies to mitigate the disease's debilitating effects. Diabetic …