The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

The Notch signaling pathway has fundamental roles in embryonic development and in the
nervous system. The current model of receptor activation involves initiation via a force …

Background Insects living in nutritionally poor environments often establish long-term
relationships with intracellular bacteria that supplement their diets and improve their …

NOTCH1 is a transmembrane receptor that initiates a cell–cell signaling pathway controlling
various cell fate specifications in metazoans. The addition of O-fucose by protein O …

The Notch signaling pathway is evolutionarily conserved across metazoan species and
plays key roles in many physiological processes. The Notch receptor is activated by two …

The canonical members of the Jagged/Serrate and Delta families of transmembrane ligands
have an extracellular, amino-terminal C2 domain that binds to phospholipids and is required …

All tissue development and replenishment relies upon the breaking of symmetries leading to
the morphological and operational differentiation of progenitor cells into more specialized …

Background Thoracic aortic dissection (TAD) is a very serious vascular condition that
requires immediate treatment. Phenotypic conversion of human aortic smooth muscle cells …

The Notch signaling pathway is a cell-cell communication system with fundamental roles in
embryonic development and the nervous system. The model of Notch receptor activation …

The Notch signaling pathway, an evolutionarily highly conserved pathway, participates in
various essential physiological processes in organisms. Activation of Notch signaling in the …