Many of the diverse functional consequences of activating group 1 metabotropic glutamate
receptors require translation of pre-existing mRNA near synapses. One of these …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Cell-surface receptors are the targets for more than 60% of current drugs. Traditionally,
optimizing the interaction of lead molecules with the binding site for the endogenous agonist …

Fragile X syndrome is a leading heritable cause of mental retardation that results from the
loss of FMR1 gene function. A Drosophila model for Fragile X syndrome, based on the loss …

In 1991 a new type of G-protein-coupled receptor (GPCR) was cloned, the type 1a
metabotropic glutamate (mGlu) receptor, which, despite possessing the defining seven …

Metabotropic glutamate (mGlu) receptors have been considered as potential targets for
neuroprotective drugs, but the lack of specific drugs has limited the development of …

Depression is a highly debilitating disorder that has been estimated to affect up to 21% of
the world population. Despite the advances in the treatment of depression with selective …

There is accumulating evidence that the nucleus accumbens (NAc) plays an important role
in the pathophysiology of depression. Given that clinical depression is marked by anhedonia …

Glutamatergic neurotransmission has been strongly implicated in the pathophysiology of
affective disorders, such as major depression and anxiety. Of all glutamate receptors, the …