The emerging inverse electron demand Diels–Alder (IEDDA) reaction stands out from other
bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and …

Noble metals comprise any of several metallic chemical elements that are outstandingly
resistant to corrosion and oxidation, even at elevated temperatures. This group is not strictly …

The transformational impact of bioorthogonal chemistries has inspired new strategies for the
in vivo synthesis of bioactive agents through non-natural means. Among these, Pd catalysts …

Bioorthogonal cleavage chemistry has been rapidly emerging as a powerful tool for
manipulation and gain-of-function studies of biomolecules in living systems. While the initial …

Bioorthogonal transformations are chemical reactions that use pathways which biological
processes do not access. Bioorthogonal chemistry provides new approaches for imaging …

Bioorthogonal chemical reactions are a thriving area of chemical research in recent years as
an unprecedented technique to dissect native biological processes through chemistry …

Prodrugs have emerged as a major strategy for addressing clinical challenges by improving
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …

Bioorthogonal catalysis using transition-metal catalysts (TMCs) provides a toolkit for the in
situ generation of imaging and therapeutic agents in biological environments. Integrating …

Palladium catalysts have been widely adopted for organic synthesis and diverse industrial
applications given their efficacy and safety, yet their biological in vivo use has been limited …

Platinum-containing drugs (eg, cisplatin) are among the most frequently used
chemotherapeutic agents. Their tremendous success has spurred research and …