Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

Sarcopenia, the lowered skeletal muscle mass, weakened skeletal muscle strength, and
reduced physical performance with aging, is a component of frailty and high-risk factor for …

Physical frailty and sarcopenia (PF&S) recapitulates all the hallmarks of aging and has
become a focus in geroscience. Factors spanning muscle-specific processes (eg …

Aging as a research pursuit is fairly new compared with traditional lines of medical research.
A growing field of investigators is focused on understanding how changes in tissue biology …

Skeletal muscle, in addition to being comprised of a heterogeneous muscle fiber population,
also includes extracellular components that do not contribute to positive tensional force …

Physical frailty and sarcopenia (PF&S) are hallmarks of aging that share a common
pathogenic background. Perturbations in protein/amino acid metabolism may play a role in …

Aging is a natural biological event that has some downsides such as increased frailty,
decline in cognitive and physical functions leading to chronical diseases, and lower quality …

Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD+) levels are
hallmarks of skeletal muscle ageing and sarcopenia,–, but it is unclear whether these …

Based on recent studies from our group and others, we hypothesize that mitochondrial
dysfunction during aging may be the root cause of mobility decline through deficits in the …

Skeletal muscles contain a large volume of water that is classified into intracellular (ICW)
and extracellular (ECW) water fractions. Nuclear magnetic resonance-based biomarkers …