Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

The spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of autosomal
dominantly inherited progressive disorders, the clinical hallmark of which is loss of balance …

The structural integrity and functional stability of organelles are prerequisites for the viability
and responsiveness of cells. Dysfunction of multiple organelles is critically involved in the …

Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …

The spinocerebellar ataxias (SCAs) comprise more than 40 autosomal dominant
neurodegenerative disorders that present principally with progressive ataxia. Within the past …

Tandem repeat diseases include the neurodegenerative disorders known as polyglutamine
(polyQ) diseases, caused by CAG repeat expansions in the coding regions of the respective …

Nuclear abnormalities are prominent in degenerative disease and progeria syndromes.
Selective autophagy of organelles is instrumental in maintaining cell homeostasis and …

In multicellular organisms, cell death is an essential aspect of life. Over the past decade, the
spectrum of different forms of regulated cell death (RCD) has expanded dramatically with …

The nuclear envelope (NE) is a specialization of the endoplasmic reticulum with distinct
biochemistry that defines inner and outer membranes connected at a pore membrane that …

The proper functioning of the cell clearance machinery is critical for neuronal health within
the central nervous system (CNS). In normal physiological conditions, the cell clearance …