The sexual dimorphism of human adipose depots

N Boulet, A Briot, J Galitzky, A Bouloumié - Biomedicines, 2022 - mdpi.com
The amount and the distribution of body fat exhibit trajectories that are sex-and human
species-specific and both are determinants for health. The enhanced accumulation of fat in …

Molecular mechanisms of perilipin protein function in lipid droplet metabolism

E Griseti, AA Bello, E Bieth, B Sabbagh… - FEBS …, 2024 - Wiley Online Library
Perilipins are abundant lipid droplet (LD) proteins present in all metazoans and also in
Amoebozoa and fungi. Humans express five perilipins, which share a similar domain …

Activin E–ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice

RC Adam, DS Pryce, JS Lee, Y Zhao… - Proceedings of the …, 2023 - National Acad Sciences
Body fat distribution is a heritable risk factor for cardiovascular and metabolic disease. In
humans, rare Inhibin beta E (INHBE, activin E) loss-of-function variants are associated with a …

Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes

P Akbari, OA Sosina, J Bovijn, K Landheer… - Nature …, 2022 - nature.com
Body fat distribution is a major, heritable risk factor for cardiometabolic disease, independent
of overall adiposity. Using exome-sequencing in 618,375 individuals (including 160,058 non …

Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity

AM Deaton, A Dubey, LD Ward, P Dornbos… - Nature …, 2022 - nature.com
Identifying genetic variants associated with lower waist-to-hip ratio can reveal new
therapeutic targets for abdominal obesity. We use exome sequences from 362,679 …

[HTML][HTML] Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids

JD Griffin, JM Buxton, JA Culver, R Barnes… - Molecular …, 2023 - Elsevier
Objective The liver is a central regulator of energy metabolism exerting its influence both
through intrinsic processing of substrates such as glucose and fatty acid as well as by …

Perilipin membrane integration determines lipid droplet heterogeneity in differentiating adipocytes

M Majchrzak, O Stojanović, D Ajjaji, KB M'barek… - Cell Reports, 2024 - cell.com
The storage of fat within lipid droplets (LDs) of adipocytes is critical for whole-body health.
Acute fatty acid (FA) uptake by differentiating adipocytes leads to the formation of at least two …

The Outlook for Crypto

N Savage - Communications of the ACM, 2022 - dl.acm.org
The Outlook for Crypto Page 1 the next guy, and then I could get more of the rewards of Bitcoin,’”
explains Neha Nerula, director of the Digital Currency Initiative in the Massachusetts Institute …

Obesity, bone marrow adiposity, and leukemia: Time to act

V Kumar, JH Stewart IV - Obesity Reviews, 2024 - Wiley Online Library
Obesity has taken the face of a pandemic with less direct concern among the general
population and scientific community. However, obesity is considered a low‐grade systemic …

Exome-wide sequencing study identified genetic variants associated with sarcopenic obesity

Q Xu, QG Zhao, XL Ma, SS Yan, BX Han… - The Journals of …, 2024 - academic.oup.com
Sarcopenic obesity (SO) is an age-related disease characterized by the coexistence of
excessive adiposity and low muscle mass or function. Although obesity and sarcopenia are …