Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …

Background Clonal hematopoiesis of indeterminate potential (CHIP)—the age-related clonal
expansion of blood stem cells with leukemia-associated mutations—is a novel …

Myeloproliferative neoplasms are associated with increased risk for thrombotic
complications. These conditions most commonly involve somatic mutations in genes that …

Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a previously
unrecognized, potent, age-related, and common risk factor for atherosclerosis. Somatic …

Clonal hematopoiesis, a condition in which acquired somatic mutations in hematopoietic
stem cells lead to the outgrowth of a mutant hematopoietic clone, is associated with a higher …

Clonal hematopoiesis arises from somatic mutations that provide a fitness advantage to
hematopoietic stem cells and the outgrowth of clones of blood cells. Clonal hematopoiesis …

Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk
of cardiovascular diseases (CVDs), putatively via inflammasome activation. We pursued an …

Abstract Background and Aims Somatic mutations in the TET2 gene that lead to clonal
haematopoiesis (CH) are associated with accelerated atherosclerosis development in mice …