During nervous system development, neurons extend axons to reach their targets and form
functional circuits. The faulty assembly or disintegration of such circuits results in disorders …

The spinal cord receives, relays and processes sensory information from the periphery and
integrates this information with descending inputs from supraspinal centres to elicit precise …

Axon guidance relies on a combinatorial code of receptor and ligand interactions that direct
adhesive/attractive and repulsive cellular responses. Recent structural data have revealed …

Microscopic features (that is, microstructure) of axons affect neural circuit activity through
characteristics such as conduction speed. To what extent axonal microstructure in white …

Compared to the other classes of glycosaminoglycans (GAG s), that is, chondroitin/dermatan
sulfate, heparin/heparan sulfate and hyaluronan, keratan sulfate (KS), have the least known …

The biological fates of the key initiator of Alzheimer's disease (AD), the amyloid precursor
protein (APP), and a family of lipoprotein receptors, the low-density lipoprotein (LDL) …

During the development of the nervous system, axons extend through complex
environments. Growth cones at the axon tip allow axons to find and innervate their …

LRP6 is a member of the low-density lipoprotein receptor superfamily of cell-surface
receptors. It is required for the activation of the Wnt/β-catenin signalling pathway. LRP6 is …

Targeting specific molecular drivers of tumor growth is a key approach in cancer therapy.
Among these targets, the low-density lipoprotein receptor-related protein 6 (LRP6), a vital …

The Wnt pathway is involved in a wide array of biological processes during development
and is deregulated in many pathological scenarios. In neurons, Wnt proteins promote both …