Array programming with NumPy

CR Harris, KJ Millman, SJ Van Der Walt, R Gommers… - Nature, 2020 - nature.com
Array programming provides a powerful, compact and expressive syntax for accessing,
manipulating and operating on data in vectors, matrices and higher-dimensional arrays …

[HTML][HTML] SciPy 1.0: fundamental algorithms for scientific computing in Python

P Virtanen, R Gommers, TE Oliphant, M Haberland… - Nature …, 2020 - nature.com
SciPy is an open-source scientific computing library for the Python programming language.
Since its initial release in 2001, SciPy has become a de facto standard for leveraging …

Specialized astrocytes mediate glutamatergic gliotransmission in the CNS

R de Ceglia, A Ledonne, DG Litvin, BL Lind, G Carriero… - Nature, 2023 - nature.com
Multimodal astrocyte–neuron communications govern brain circuitry assembly and function.
For example, through rapid glutamate release, astrocytes can control excitability, plasticity …

CellProfiler 4: improvements in speed, utility and usability

DR Stirling, MJ Swain-Bowden, AM Lucas… - BMC …, 2021 - Springer
Background Imaging data contains a substantial amount of information which can be difficult
to evaluate by eye. With the expansion of high throughput microscopy methodologies …

Dynamics of CTCF-and cohesin-mediated chromatin looping revealed by live-cell imaging

M Gabriele, HB Brandão, S Grosse-Holz, A Jha… - Science, 2022 - science.org
Animal genomes are folded into loops and topologically associating domains (TADs) by
CTCF and loop-extruding cohesins, but the live dynamics of loop formation and stability …

[HTML][HTML] Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

NE Reticker-Flynn, W Zhang, JA Belk, PA Basto… - Cell, 2022 - cell.com
For many solid malignancies, lymph node (LN) involvement represents a harbinger of
distant metastatic disease and, therefore, an important prognostic factor. Beyond its utility as …

A massive rock and ice avalanche caused the 2021 disaster at Chamoli, Indian Himalaya

DH Shugar, M Jacquemart, D Shean, S Bhushan… - Science, 2021 - science.org
On 7 February 2021, a catastrophic mass flow descended the Ronti Gad, Rishiganga, and
Dhauliganga valleys in Chamoli, Uttarakhand, India, causing widespread devastation and …

Multimodal data integration using machine learning improves risk stratification of high-grade serous ovarian cancer

KM Boehm, EA Aherne, L Ellenson, I Nikolovski… - Nature cancer, 2022 - nature.com
Patients with high-grade serous ovarian cancer suffer poor prognosis and variable response
to treatment. Known prognostic factors for this disease include homologous recombination …

Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning

NF Greenwald, G Miller, E Moen, A Kong, A Kagel… - Nature …, 2022 - nature.com
A principal challenge in the analysis of tissue imaging data is cell segmentation—the task of
identifying the precise boundary of every cell in an image. To address this problem we …

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays

A Chen, S Liao, M Cheng, K Ma, L Wu, Y Lai, X Qiu… - Cell, 2022 - cell.com
Spatially resolved transcriptomic technologies are promising tools to study complex
biological processes such as mammalian embryogenesis. However, the imbalance between …