Comprehensive investigation of pathway enrichment methods for functional interpretation of LC–MS global metabolomics data
Background: Global or untargeted metabolomics is widely used to comprehensively
investigate metabolic profiles under various pathophysiological conditions such as …
investigate metabolic profiles under various pathophysiological conditions such as …
Hyperinflammatory immune response and COVID-19: a double edged sword
LY Tan, TV Komarasamy… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease-19 (COVID-19) elicited by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has caused devastating health, economic and social impact …
coronavirus 2 (SARS-CoV-2) has caused devastating health, economic and social impact …
Alzheimer's‐like signaling in brains of COVID‐19 patients
Introduction The mechanisms that lead to cognitive impairment associated with COVID‐19
are not well understood. Methods Brain lysates from control and COVID‐19 patients were …
are not well understood. Methods Brain lysates from control and COVID‐19 patients were …
[HTML][HTML] Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling
Long COVID, a type of post-acute sequelae of SARS-CoV-2 (PASC), has been associated
with sustained elevated levels of immune activation and inflammation. However, the …
with sustained elevated levels of immune activation and inflammation. However, the …
Tumor microenvironment activated photoacoustic-fluorescence bimodal nanoprobe for precise chemo-immunotherapy and immune response tracing of glioblastoma
Synergistic therapy strategy and prognostic monitoring of glioblastoma's immune response
to treatment are crucial to optimize patient care and advance clinical outcomes. However …
to treatment are crucial to optimize patient care and advance clinical outcomes. However …
Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome
Introduction The diagnosis of COVID-19 is normally based on the qualitative detection of
viral nucleic acid sequences. Properties of the host response are not measured but are key …
viral nucleic acid sequences. Properties of the host response are not measured but are key …
The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis
AF Almulla, T Supasitthumrong… - BMC Infectious …, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is accompanied by activated
immune-inflammatory pathways and oxidative stress, which both induce indoleamine-2, 3 …
immune-inflammatory pathways and oxidative stress, which both induce indoleamine-2, 3 …
Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation
Severe COVID-19 is characterized by an increase in the number and changes in the
function of innate immune cells including neutrophils. However, it is not known how the …
function of innate immune cells including neutrophils. However, it is not known how the …
Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19
SARS-CoV-2 causes major disturbances in serum metabolite levels, associated with
severity of the immune response. Despite the numerous advantages of urine for biomarker …
severity of the immune response. Despite the numerous advantages of urine for biomarker …