Since the early 1980s, an intensive effort has been focused on the development of orally
effective and long-acting inhibitors of renin. During this time, in vitro potency has increased …

ABSTRACT A cDNA clone encoding human angiotensinogen was isolated from a cDNA
library prepared from human liver mRNA and used to isolate the angiotensinogen gene. The …

The full-length bovine lung prostaglandin (PG) F synthase cDNA was constructed from
partial cDNA clones and ligated into bacterial expression vector pUC8 to develop …

Background The renin-angiotensin-aldosterone system (RAS) cascade is a major target for
the clinical management of hypertension. Although inhibitors of various components of this …

Background Angiotensinogen (ANG) is a macromolecular precursor of angiotensin, which
regulates blood pressure and electrolyte balance. ANG is specifically cleaved by renin, an …

Transfection of Chinese hamster ovary cells with an expression plasmid containing a full
length human angiotensinogen cDNA has provided cell lines that secrete recombinant …

Human high molecular weight kininogen (HK), a single chain plasma glycoprotein, serves
as a cofactor in the contact system of blood coagulation. After cleavage by human plasma …

A kit for carrying out an immunoenzymological assay for protein, containing a diagnostic
reagent consisting of a hybrid protein comprising, in order, a polypeptide P1 which is an N …

Angiotensinogen is a blood protein that plays a critical role in the regulation of blood
pressure in the body. This protein exists in two forms, oxidised and reduced, determined by …

Angiotensinogen is a blood protein that plays a critical role in the regulation of blood
pressure in the body. This protein exists in two forms, oxidised and reduced, determined by …