Nucleic acids are emerging as powerful and functional biomaterials due to their molecular
recognition ability, programmability, and ease of synthesis and chemical modification …

First studies on thrombin-inhibiting DNA aptamers were reported in 1992, and since then a
large number of anticoagulant aptamers has been discovered. TBA–also named HD1, a 15 …

The G-quadruplex architecture is a peculiar structure adopted by guanine-rich
oligonucleotidic sequences, and, in particular, by several aptamers, including the thrombin …

Aptamers are powerful candidates for molecular imaging applications due to a number of
attractive features, including rapid blood clearance and tumor penetration. We carried out …

Guanine's array of hydrogen bond donors and acceptors lead it to take part in structures as
diverse as B-DNA, Z-DNA, hairpins, cruciforms, triplexes, and G-quadruplexes; these …

Highly specific and tight-binding nucleic acid aptamers have been selected against a variety
of molecular targets for over 20 years. A significant proportion of these oligonucleotides …

A 15-mer DNA aptamer (named TBA) adopts a G-quadruplex structure that strongly inhibits
fibrin-clot formation by binding to thrombin. We have performed thermodynamic analysis …

The thrombin binding aptamer (TBA) is a well characterized chair-like, antiparallel
quadruplex structure that binds specifically to thrombin at nanomolar concentrations and …

Aptamers are structural single-stranded oligonucleotides generated in vitro to bind to a
specific target molecule. Aptamers' versatility can be enhanced with nucleic acid mimics …

Nucleic acid biosensors have a growing number of applications in genetics and
biomedicine. This contribution is a critical review of the current state of the art concerning the …