Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against
infections and regulates the innate and acquired immune response. IL-18 is produced by …

During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …

Cytokines are molecular messengers that allow the cells of the immune system to
communicate with one another to generate a coordinated, robust, but self-limited response …

Although interleukin-18 is structurally homologous to IL-1 and its receptor belongs to the IL-
1R/Toll-like receptor (TLR) superfamily, its function is quite different from that of IL-1. IL-18 is …

The interleukin‐1 (IL‐1), IL‐18, and IL‐33 families of cytokines are related by mechanism of
origin, receptor structure, and signal transduction pathways utilized. All three cytokines are …

Interleukin (IL)-18, a member of the IL-1 superfamily, is a pro-inflammatory cytokine that is
structurally similar to IL-1β. IL-18 promotes the production of interferon gamma (IFN-γ) and …

NK cells constitutively express monocyte-derived cytokine (monokine) receptors and secrete
cytokines and chemokines following monokine stimulation, and are therefore a critical …

IL-18 is a potent proinflammatory cytokine able to induce IFNγ, GM-CSF, TNFα and IL-1 in
immunocompetent cells, to activate killing by lymphocytes, and to up-regulate the …

Abstract IL-12 and IL-18 synergistically enhance IFN-γ mRNA transcription by activating
STAT4 and AP-1, respectively. However, it is still unknown how STAT4/AP-1 elicit IFN-γ …