Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Trauma remains a leading cause of death worldwide, and most early preventable deaths in
both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Importance Critical bleeding is associated with a high mortality rate in patients with trauma.
Hemorrhage is exacerbated by a complex derangement of coagulation, including an acute …

Normal haemostasis depends on an intricate balance between mechanisms of bleeding and
mechanisms of thrombosis, and this balance can be altered after traumatic brain injury (TBI) …

Background Effective treatment of trauma-induced coagulopathy is important; however, the
optimal therapy is still not known. We aimed to compare the efficacy of first-line therapy …

Background Major haemorrhage is a clinical emergency that results in morbidity and
mortality: practice guidance is important to reduce these risks. Delayed recognition of …

Background: Patients with substantive bleeding usually require transfusion and/or (re-)
operation. Red blood cell (RBC) transfusion is independently associated with a greater risk …

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