Convolutional neural network denoising in fluorescence lifetime imaging microscopy (FLIM)

V Mannam, Y Zhang, X Yuan, T Hato… - … microscopy in the …, 2021 - spiedigitallibrary.org
Fluorescence lifetime imaging microscopy (FLIM) systems are limited by their slow
processing speed, low signal-to-noise ratio (SNR), and expensive and challenging …

Deep learning-based super-resolution fluorescence microscopy on small datasets

V Mannam, Y Zhang, X Yuan… - Single Molecule …, 2021 - spiedigitallibrary.org
Fluorescence microscopy has enabled a dramatic development in modern biology by
visualizing biological organ-isms with micrometer scale resolution. However, due to the …

Overcoming the fundamental limitation of frequency-domain fluorescence lifetime imaging microscopy spatial resolution

X Yuan, V Mannam, Y Zhang… - Single Molecule …, 2021 - spiedigitallibrary.org
We propose and demonstrate the first analytical model of the spatial resolution of frequency-
domain (FD) fluorescence lifetime imaging microscopy (FLIM) that explains how it is …

[图书][B] Overcoming fundamental limits of three-dimensional in vivo fluorescence imaging using machine learning

VV Mannam - 2022 - search.proquest.com
In vivo fluorescence imaging is a powerful tool for understanding and characterizing
biological systems. For example, with the help of in vivo fluorescence imaging, one can …