Mitochondria are essential for tumor growth and progression. However, the heavy demand
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …

Heat shock proteins (Hsps) are overexpressed in a wide range of human cancers and are
implicated in tumor cell proliferation, differentiation, invasion, metastasis, death, and …

Autoantibodies against autologus tumor‐associated antigens have been detected in the
asymptomatic stage of cancer and can thus serve as biomarkers for early cancer diagnosis …

Hsp60 in eukaryotes is considered typically a mitochondrial chaperone (also called Cpn60)
but in the last few years it has become clear that it also occurs in the cytosol, the cell surface …

The 60 kDa heat shock protein (Hsp60) is classically known as a mitochondrial chaperonin
protein working together with co-chaperonin 10 kDa heat shock protein (Hsp10). This …

Heat shock proteins (HSPs) are a large molecular chaperone family classified by their
molecular weights, including HSP27, HSP40, HSP60, HSP70, HSP90, and HSP110. HSPs …

Introduction: Hsp60 (Cpn60) assembles into a tetradecamer that interacts with the co-
chaperonin Hsp10 (Cpn10) to assist client polypeptides to fold, but it also has other roles …

Mutations in superoxide dismutase 1 (SOD1) cause familial ALS. Mutant SOD1 preferentially
associates with the cytoplasmic face of mitochondria from spinal cords of rats and mice …

Molecular chaperones, many of which are heat-shock proteins (HSPs), are an important
class of molecules with various functions. Pathological conditions in which chaperones …

Mitochondria are cell organelles involved in processes of cell life and death, and therefore
also in tumoral transformation. Indeed, mitochondria dysfunction is a prominent feature of …