The extracellular matrix (ECM) is a major component of the biomechanical environment with
which cells interact, and it plays important roles in both normal development and disease …

Muscle development involves a series of morphogenetic events including cell fusion,
migration and epidermal attachment. At various points in this complex developmental …

Axons are cable-like neuronal processes wiring the nervous system. They contain parallel
bundles of microtubules as structural backbones, surrounded by regularly spaced actin rings …

Chitin contributes to the rigidity of the insect cuticle and serves as an attachment matrix for
other cuticular proteins. Deficiency of chitin results in abnormal embryos, cuticular structural …

The correct outgrowth of axons is essential for the development and regeneration of nervous
systems. Axon growth is primarily driven by microtubules. Key regulators of microtubules in …

The development of the musculoskeletal system is a great model to study the interplay
between chemical and mechanical inter-tissue signaling in cell adhesion, tissue …

Muscle attachment sites (MASs, apodemes) in insects and other arthropods involve
specialized epithelial cells, called tendon cells or tenocytes, that adhere to apical …

Spectraplakins are evolutionarily well conserved cytoskeletal linker molecules that are true
members of three protein families: plakins, spectrins and Gas2-like proteins. Spectraplakin …

F-actin networks are important structural determinants of cell shape and morphogenesis.
They are regulated through a number of actin-binding proteins. The function of many of …

The different cytoskeletal networks in a cell are responsible for many fundamental cellular
processes. Current studies have shown that spectraplakins, cytoskeletal crosslinkers that …