Obesity is associated with insulin resistance and a state of abnormal inflammatory response.
The Toll-like receptor (TLR) 4 has an important role in inflammation and immunity, and its …

Aims/hypothesis A high-fat dietary intake induces obesity and subclinical inflammation,
which play important roles in insulin resistance. Recent studies have suggested that …

In diet-induced obesity, hypothalamic and systemic inflammatory factors trigger intracellular
mechanisms that lead to resistance to the main adipostatic hormones, leptin and insulin …

Molecules from animal venoms are promising candidates for the development of new drugs.
Previous in vitro studies have shown that the venom of the spider Phoneutria nigriventer …

Recent studies have found that cellular self‐renewal capacity in brain cancer is
heterogeneous, with only stem‐like cells having this property. A link between adult stem …

Immunomodulation has been considered an important approach in the treatment of
malignant tumours. However, the modulation of innate immune cells remains an …

A newly established GM7 cell line was derived from the tumor tissue of a 65-year-old man
surgically treated for a relapse of glioblastoma multiforme that occurred 10 months after first …

Background Glioblastoma (GB) cells have the ability to migrate and infiltrate the normal
parenchyma, leading to the formation of recurrent tumors often adjacent to the surgical …

Glioblastomas (GBs) are responsible for a higher mortality rate among gliomas,
corresponding to more than 50% of them and representing a challenge in terms of therapy …

Astrocytomas, or glioblastomas, are aggressive malignancies of the central nervous system
which has poor prognosis, even when submitted to surgery, radiation and chemotherapy …