The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators

LL Chen, YG Fan, LX Zhao, Q Zhang, ZY Wang - Bioorganic chemistry, 2023 - Elsevier
Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

[HTML][HTML] Curcumin, inflammation, and neurological disorders: How are they linked?

P Garodia, M Hegde, AB Kunnumakkara… - Integrative Medicine …, 2023 - Elsevier
Background: Despite the extensive research in recent years, the current treatment modalities
for neurological disorders are suboptimal. Curcumin, a polyphenol majorly found in …

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy

C Liu, X Yan, Y Zhang, M Yang, Y Ma, Y Zhang… - Journal of …, 2022 - Springer
Background Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by
diffuse inflammation of the colonic mucosa and a relapsing and remitting course. The current …

Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation

J Kou, J Shi, Y He, J Hao, H Zhang, D Luo… - Acta Pharmacologica …, 2022 - nature.com
Luteolin is a flavonoid in a variety of fruits, vegetables, and herbs, which has shown anti-
inflammatory, antioxidant, and anti-cancer neuroprotective activities. In this study, we …

[HTML][HTML] Magnoflorine improves cognitive deficits and pathology of Alzheimer's disease via inhibiting of JNK signaling pathway

L Zhong, Y Qin, M Liu, J Sun, H Tang, Y Zeng, J Zhang… - Phytomedicine, 2023 - Elsevier
Background Cognitive deficit is the main clinical feature of Alzheimer's disease (AD), and the
massive death of neuronal cells is the leading cause of cognitive deficits. So, there is an …

Oxidative stress and natural antioxidants: Back and forth in the neurological mechanisms of Alzheimer's Disease

S Mani, R Dubey, IC Lai, MA Babu… - Journal of …, 2023 - journals.sagepub.com
Alzheimer's disease (AD) is characterized by the progressive degeneration of neuronal
cells. With the increase in aged population, there is a prevalence of irreversible …

Sleep–Wake Disorders in Alzheimer's Disease: A Review

YY Sun, Z Wang, HY Zhou… - ACS Chemical …, 2022 - ACS Publications
Alzheimer's disease (AD) is a multifactorial disease, and it has become a serious health
problem in the world. Senile plaques (SPs) and neurofibrillary tangles (NFTs) are two main …

[HTML][HTML] The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington's disease R6/1 mice

M Espina, N Di Franco, M Brañas-Navarro… - Neurobiology of …, 2023 - Elsevier
Increasing evidence indicates that a key factor in neurodegenerative diseases is the
activation of the unfolded protein response (UPR) caused by an accumulation of misfolded …

Cornuside is a potential agent against Alzheimer's disease via orchestration of reactive astrocytes

JZ Shi, XM Zheng, YF Zhou, LY Yun, DM Luo, JJ Hao… - Nutrients, 2022 - mdpi.com
Cornuside is an iridoid glycoside from Cornus officinalis, with the activities of anti-
inflammatory, antioxidant, anti-mitochondrial dysfunction, and neuroprotection. In the …

Targeting endoplasmic reticulum stress using natural products in neurological disorders

A Jangra, M Verma, D Kumar, M Rachamalla… - Neuroscience & …, 2022 - Elsevier
The primary aim of this review is to summarize the literature on natural products that are
effective in the treatment of various neurological disorders by targeting endoplasmic …