Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …

p53 is an important tumor suppressor gene, which is stimulated by cellular stress like
ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to …

During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …

Glioblastoma multiform (GBM) is the most common brain tumor characterized by a dismal
prognosis. GBM cancer stem cells (gCSC) or tumor-initiating cells are the cell population …

The p53 protein family is the most studied protein family of all. Sequence analysis and
structure determination have revealed a high similarity of crucial domains between p53, p63 …

In mammals, the p53 family comprises two additional members, p63 and p73 (hereafter
referred to as TP 53, TP 63, and TP 73, respectively). The usage of two alternative promoters …

Learning and memory deficits are early clinical manifestations of Huntington's disease (HD).
These cognitive impairments have been mainly associated with frontostriatal HD pathology; …

It has been shown that p53 has a critical role in the differentiation and functionality of various
multipotent progenitor cells. P53 mutations can lead to genome instability and subsequent …

Significance: The p53 family of transcription factors, including p53, p63, and p73, plays key
roles in both biological and pathological processes, including cancer and neural …

Cancer develops and progresses often by inactivating p53. Here, we unveil n erve g rowth f
actor r eceptor (NGFR, p75NTR or CD271) as a novel p53 inactivator. p53 activates NGFR …