Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …
Global issues in allergy and immunology: parasitic infections and allergy
AA Cruz, PJ Cooper, CA Figueiredo… - Journal of Allergy and …, 2017 - Elsevier
Allergic diseases are on the increase globally in parallel with a decrease in parasitic
infection. The inverse association between parasitic infections and allergy at an ecological …
infection. The inverse association between parasitic infections and allergy at an ecological …
DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study
Background Epigenetic mechanisms could alter the airway epithelial barrier and ultimately
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …
[HTML][HTML] The application of multi-omics in the respiratory microbiome: Progresses, challenges and promises
The study of the respiratory microbiome has entered a multi-omic era. Through integrating
different omic data types such as metagenome, metatranscriptome, metaproteome …
different omic data types such as metagenome, metatranscriptome, metaproteome …
[HTML][HTML] Epigenomics and transcriptomics in the prediction and diagnosis of childhood asthma: are we there yet?
E Forno, JC Celedón - Frontiers in Pediatrics, 2019 - frontiersin.org
Asthma is the most common non-communicable chronic disease of childhood. Despite its
high prevalence, to date we lack methods that are both efficient and accurate in diagnosing …
high prevalence, to date we lack methods that are both efficient and accurate in diagnosing …
The current state of omics technologies in the clinical management of asthma and allergic diseases
Objective To review the state of omics science specific to asthma and allergic diseases and
discuss the current and potential applicability of omics in clinical disease prediction …
discuss the current and potential applicability of omics in clinical disease prediction …
DNA methylation and allergic sensitizations: a genome‐scale longitudinal study during adolescence
Background The presence of allergic sensitization has a major influence on the
development and course of common childhood conditions such as asthma and rhinitis. The …
development and course of common childhood conditions such as asthma and rhinitis. The …
A strategy for high‐dimensional multivariable analysis classifies childhood asthma phenotypes from genetic, immunological, and environmental factors
N Krautenbacher, N Flach, A Böck, K Laubhahn… - Allergy, 2019 - Wiley Online Library
Background Associations between childhood asthma phenotypes and genetic,
immunological, and environmental factors have been previously established. Yet, strategies …
immunological, and environmental factors have been previously established. Yet, strategies …
Whole-genome sequencing identifies novel functional loci associated with lung function in Puerto Rican youth
EY Lee, ACY Mak, D Hu, S Sajuthi… - American journal of …, 2020 - atsjournals.org
Rationale: Puerto Ricans have the highest childhood asthma prevalence in the United
States (23.6%); however, the etiology is uncertain. Objectives: In this study, we sought to …
States (23.6%); however, the etiology is uncertain. Objectives: In this study, we sought to …
Transcriptomics of atopy and atopic asthma in white blood cells from children and adolescents
Early allergic sensitisation (atopy) is the first step in the development of allergic diseases
such as atopic asthma later in life. Genes and pathways associated with atopy and atopic …
such as atopic asthma later in life. Genes and pathways associated with atopy and atopic …