The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining …
Melatonin is a neurohormone associated with sleep and wakefulness and is mainly
produced by the pineal gland. Numerous physiological functions of melatonin have been …
produced by the pineal gland. Numerous physiological functions of melatonin have been …
Melatonin receptor ligands: a pharmaco‐chemical perspective
JA Boutin, PA Witt‐Enderby, C Sotriffer… - Journal of pineal …, 2020 - Wiley Online Library
Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …
decades. Inspection of approximately 80 publications in the field revealed that most …
Indole-based melatonin analogues: Synthetic approaches and biological activity
SY Wang, XC Shi, P Laborda - European Journal of Medicinal Chemistry, 2020 - Elsevier
Melatonin is a natural hormone primarily released by the pineal gland that regulates the
sleep-wake cycles. The diverse biological applications of melatonin, together with the need …
sleep-wake cycles. The diverse biological applications of melatonin, together with the need …
Ultra-broadband terahertz fingerprint spectrum of melatonin with vibrational mode analysis
J Shen, Z Zhu, Z Zhang, C Guo, J Zhang, G Ren… - … Acta Part A: Molecular …, 2021 - Elsevier
Melatonin (MLT), as a neurotransmitter and an endogenous neurohormone, plays an
important role in physiological functions through interactions with specific receptors. The …
important role in physiological functions through interactions with specific receptors. The …
Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes
F Radogna, L Paternoster, M De Nicola… - Toxicology and applied …, 2009 - Elsevier
Melatonin is a modified tryptophan with potent biological activity, exerted by stimulation of
specific plasma membrane (MT1/MT2) receptors, by lower affinity intracellular enzymatic …
specific plasma membrane (MT1/MT2) receptors, by lower affinity intracellular enzymatic …
Analysis of Structure−Activity Relationships for MT2 Selective Antagonists by Melatonin MT1 and MT2 Receptor Models
Three-dimensional homology models of human MT1 and MT2 melatonin receptors were
built with the aim to investigate the structure− activity relationships (SARs) of MT2 selective …
built with the aim to investigate the structure− activity relationships (SARs) of MT2 selective …
In silico drug discovery of melatonin receptor ligands with therapeutic potential
Introduction The neurohormone melatonin (N-acetyl-5-methoxytryptamine) regulates
circadian rhythms exerting a variety of effects in the central nervous system and in periphery …
circadian rhythms exerting a variety of effects in the central nervous system and in periphery …
Industrial and academic approaches to the search for alternative melatonin receptor ligands: An historical survey
A Bedini, JA Boutin, C Legros… - Journal of Pineal …, 2024 - Wiley Online Library
The search for melatonin receptor agonists formed the main part of melatonin medicinal
chemistry programs for the last three decades. In this short review, we summarize the two …
chemistry programs for the last three decades. In this short review, we summarize the two …
Synthesis of 2-substituted benzofurans and indoles using functionalized titanium benzylidene reagents on solid phase
C Macleod, GJ McKiernan, EJ Guthrie… - The Journal of …, 2003 - ACS Publications
Titanium (IV) benzylidenes bearing a masked oxygen or nitrogen nucleophile in the ortho
position were generated from thioacetals, using low-valent titanocene complex, Cp2Ti [P …
position were generated from thioacetals, using low-valent titanocene complex, Cp2Ti [P …
[HTML][HTML] A molecular and chemical perspective in defining melatonin receptor subtype selectivity
KH Chan, YH Wong - International Journal of Molecular Sciences, 2013 - mdpi.com
Melatonin is primarily synthesized and secreted by the pineal gland during darkness in a
normal diurnal cycle. In addition to its intrinsic antioxidant property, the neurohormone has …
normal diurnal cycle. In addition to its intrinsic antioxidant property, the neurohormone has …