Melatonin is a neurohormone associated with sleep and wakefulness and is mainly
produced by the pineal gland. Numerous physiological functions of melatonin have been …

Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …

Melatonin is a natural hormone primarily released by the pineal gland that regulates the
sleep-wake cycles. The diverse biological applications of melatonin, together with the need …

Melatonin (MLT), as a neurotransmitter and an endogenous neurohormone, plays an
important role in physiological functions through interactions with specific receptors. The …

Melatonin is a modified tryptophan with potent biological activity, exerted by stimulation of
specific plasma membrane (MT1/MT2) receptors, by lower affinity intracellular enzymatic …

Three-dimensional homology models of human MT1 and MT2 melatonin receptors were
built with the aim to investigate the structure− activity relationships (SARs) of MT2 selective …

Introduction The neurohormone melatonin (N-acetyl-5-methoxytryptamine) regulates
circadian rhythms exerting a variety of effects in the central nervous system and in periphery …

The search for melatonin receptor agonists formed the main part of melatonin medicinal
chemistry programs for the last three decades. In this short review, we summarize the two …

Titanium (IV) benzylidenes bearing a masked oxygen or nitrogen nucleophile in the ortho
position were generated from thioacetals, using low-valent titanocene complex, Cp2Ti [P …

Melatonin is primarily synthesized and secreted by the pineal gland during darkness in a
normal diurnal cycle. In addition to its intrinsic antioxidant property, the neurohormone has …