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Background Abstracts of presentations at scientific meetings are usually available only in
conference proceedings. If subsequent full publication of results reported in these abstracts …

Drugs produce their therapeutic effects by modulating specific targets, and there are 89
innovative targets of first-in-class drugs approved in 2004–17, each with information about …

Publication bias is a well‐known threat to the validity of meta‐analyses and, more broadly,
the reproducibility of scientific findings. When policies and recommendations are predicated …

Background Neovascular age‐related macular degeneration (AMD) is the leading cause of
legal blindness in elderly populations of industrialised countries. Bevacizumab (Avastin®) …

Purpose Since 2012, PCORI has been funding patient-centered comparative effectiveness
research with a requirement for engaging patients and other stakeholders in the research, a …

Objective To collect and classify reported reasons for recruitment failure in discontinued
randomized controlled trials (RCTs) and to assess reporting quality. Methods We …

Background Information and communication technologies have long become prominent
components of health systems. Rapid advances in digital technologies and data science …

BACKGROUND: Trial discontinuation and nonpublication represent potential waste in
research resources and lead to compromises in medical evidence. Pediatric trials may be …

Background Clinical trials that end prematurely (or “terminate”) raise financial, ethical, and
scientific concerns. The extent to which the results of such trials are disseminated and the …