Remyelination, the myelin regenerative response that follows demyelination, restores
saltatory conduction and function and sustains axon health. Its declining efficiency with …

B cells represent a relatively minor cell population within both the healthy and diseased
central nervous system (CNS), yet they can have profound effects. This is emphasized in …

Despite the large number of immunomodulatory or immunosuppressive treatments available
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …

B cells play a central role in the immune system through the production of antibodies. During
the past two decades, it has become increasingly clear that B cells also have the capacity to …

Multiple sclerosis (MS) is the most frequent demyelinating disease and a leading cause for
disability in young adults. Despite significant advances in immunotherapies in recent years …

The immune system's role is much more than merely recognizing self vs. non-self and
involves maintaining homeostasis and integrity of the organism starting from early …

Multiple sclerosis (MS) is a chronic, autoimmune, and neurodegenerative disease of the
central nervous system (CNS) that affects myelin. The etiology of MS is unclear, although a …

With the ability to induce T cell activation and elicit humoral responses, B cells are generally
considered as effectors of the immune system. However, the emergence of regulatory B cells …

Oligodendrocytes and their progenitors are glial cells in the central nervous system, which
have been mainly implicated with the homeostatic roles of axonal myelin ensheathment but …

Remyelination relies on the repair of damaged myelin sheaths, involving microglia cells,
oligodendrocyte precursor cells (OPCs), and mature oligodendrocytes. This process drives …