The degree of frailty as a translational measure of health in aging
Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …
outcomes. We review how the degree of frailty conditions the development of late-life …
Frailty screening and interventions: considerations for clinical practice
Over the past 100 years, advances in medicine and public health have led to a nearly 2-fold
increase in average lifespan. 1 Approximately 8.5% of the global population is 65 years or …
increase in average lifespan. 1 Approximately 8.5% of the global population is 65 years or …
Efficacy and safety of dapagliflozin according to frailty in patients with heart failure: a prespecified analysis of the DELIVER trial
Background: Frailty is increasing in prevalence. Because patients with frailty are often
perceived to have a less favorable risk/benefit profile, they may be less likely to receive new …
perceived to have a less favorable risk/benefit profile, they may be less likely to receive new …
Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged≥ 75 years: a randomized clinical trial
JD Williamson, MA Supiano, WB Applegate… - Jama, 2016 - jamanetwork.com
Importance The appropriate treatment target for systolic blood pressure (SBP) in older
patients with hypertension remains uncertain. Objective To evaluate the effects of intensive …
patients with hypertension remains uncertain. Objective To evaluate the effects of intensive …
Longer-term all-cause and cardiovascular mortality with intensive blood pressure control: a secondary analysis of a randomized clinical trial
Importance The Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive
blood pressure control reduced cardiovascular morbidity and mortality. However, the legacy …
blood pressure control reduced cardiovascular morbidity and mortality. However, the legacy …
[HTML][HTML] Effect of intensive blood-pressure treatment on patient-reported outcomes
DR Berlowitz, CG Foy, LE Kazis, LP Bolin… - … England Journal of …, 2017 - Mass Medical Soc
Background The previously published results of the Systolic Blood Pressure Intervention
Trial showed that among participants with hypertension and an increased cardiovascular …
Trial showed that among participants with hypertension and an increased cardiovascular …
Sacubitril/valsartan and frailty in patients with heart failure and preserved ejection fraction
Background Frailty is an increasingly common problem, and frail patients are less likely to
receive new pharmacologic therapies because the risk–benefit profile is perceived to be …
receive new pharmacologic therapies because the risk–benefit profile is perceived to be …
Effect of vitamin D3 and omega-3 fatty acid supplementation on risk of frailty: an ancillary study of a randomized clinical trial
AR Orkaby, R Dushkes, R Ward, L Djousse… - JAMA network …, 2022 - jamanetwork.com
Importance Preventive strategies for frailty are needed. Whether supplements with anti-
inflammatory properties, such as vitamin D 3 or marine omega-3 fatty acids, are useful for …
inflammatory properties, such as vitamin D 3 or marine omega-3 fatty acids, are useful for …
Systolic blood pressure trajectory, frailty, and all-cause mortality> 80 years of age: cohort study using electronic health records
R Ravindrarajah, NC Hazra, S Hamada, J Charlton… - Circulation, 2017 - Am Heart Assoc
Background: Clinical trials show benefit from lowering systolic blood pressure (SBP) in
people≥ 80 years of age, but nonrandomized epidemiological studies suggest lower SBP …
people≥ 80 years of age, but nonrandomized epidemiological studies suggest lower SBP …
The frailty syndrome and outcomes in the TOPCAT trial
NA Sanders, MA Supiano, EF Lewis… - European journal of …, 2018 - Wiley Online Library
Aims The impact of frailty on outcomes in randomized heart failure with preserved ejection
fraction (HFpEF) trials has not been previously reported. This analysis sought to characterize …
fraction (HFpEF) trials has not been previously reported. This analysis sought to characterize …