Black men with prostate cancer have historically had worse outcomes than white men with
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …

Codon 72 is a hotspot of polymorphisms in the TP53 gene, which encodes a hub protein in
the protein–protein interaction network of p53. It is thus a central player in the apoptotic …

In prostate cancer, race/ethnicity is the highest risk factor after adjusting for age. African
Americans have more aggressive tumors at every clinical stage of the disease, resulting in …

Simple Summary We investigated the influence of genetic variants, called single nucleotide
polymorphisms (SNP) in the TP53 tumour suppressor gene, on cancer risk, clinical features …

Conditionally reprogrammed cells (CRCs) are epithelial cells that are directly isolated from
patients' specimens and propagated in vitro with feeder cells and a Rho kinase inhibitor. A …

The tumor suppressor gene p53 plays an important role in the stress response of the cell
and is mutated in 50% of all human tumors. The p53 Arg72Pro single-nucleotide …

Cell cycle deregulation is common in human cancer. Alterations of the tumor-suppressor
gene p53 and its downstream effector p21 have been indicated in the development of …

Many studies have been conducted to explore the association between p53 codon 72
polymorphism and prostate cancer (PCa). However, the results remain inconsistent …

Background Molecular and epidemiological evidence demonstrate that altered gene
expression and single nucleotide polymorphisms in the apoptotic pathway are linked to …

Background Breast cancer cell lines are widely used tools to investigate breast cancer
biology and to develop new therapies. Breast cancer tissue contains molecularly …