A review exploring therapeutic worth of 1, 3, 4-oxadiazole tailored compounds
1, 3, 4-Oxadiazole, a five-membered aromatic ring can be seen in a number of synthetic
molecules. The peculiar structural feature of 1, 3, 4-oxadiazole ring with pyridine type of …
molecules. The peculiar structural feature of 1, 3, 4-oxadiazole ring with pyridine type of …
Groundbreaking anticancer activity of highly diversified oxadiazole scaffolds
A Benassi, F Doria, V Pirota - International journal of molecular sciences, 2020 - mdpi.com
Nowadays, an increasing number of heterocyclic-based drugs found application in
medicinal chemistry and, in particular, as anticancer agents. In this context, oxadiazoles …
medicinal chemistry and, in particular, as anticancer agents. In this context, oxadiazoles …
Discovery of novel benzophenone integrated derivatives as anti-Alzheimer's agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach
The most commonly accepted hypothesis of Alzheimer's disease (AD) is the amyloid
hypothesis caused due to formation of accumulation of Aβ42 isoform, which leads to …
hypothesis caused due to formation of accumulation of Aβ42 isoform, which leads to …
Design, synthesis, biological evaluation and molecular docking of new 1, 3, 4-oxadiazole homonucleosides and their double-headed analogs as antitumor agents
A novel series of homonucleosides and their double-headed analogs containing
theophylline, 1, 3, 4-oxadiazole, and variant nucleobases was designed and synthesized …
theophylline, 1, 3, 4-oxadiazole, and variant nucleobases was designed and synthesized …
Exploring target site interactions of 1, 3, 4-Oxadiazole/1, 3, 4-thiadiazole derivatives: Synthesis, characterization in vitro anti-urease and in silico molecular docking …
Urease enzyme is one of the major causes of severe health issues including urinary catheter
encrustation, gastric cancer, duodenal ulcer and peptic ulcer. In search for potent anti …
encrustation, gastric cancer, duodenal ulcer and peptic ulcer. In search for potent anti …
[HTML][HTML] Synthesis, docking and biological evaluation of thiadiazole and oxadiazole derivatives as antimicrobial and antioxidant agents
MJN Khadri, AB Begum, MK Sunil, SA Khanum - Results in Chemistry, 2020 - Elsevier
A series of potential biological active substituted thiadiazoles 5a-j and oxadiazoles 6a-j were
obtained via a multistep synthesis sequence with a simple and convenient approach by …
obtained via a multistep synthesis sequence with a simple and convenient approach by …
BP-1T, an antiangiogenic benzophenone-thiazole pharmacophore, counteracts HIF-1 signalling through p53/MDM2-mediated HIF-1α proteasomal degradation
Hypoxia is a feature of all solid tumours, contributing to tumour progression. Activation of HIF-
1α plays a critical role in promoting tumour angiogenesis and metastasis. Since its …
1α plays a critical role in promoting tumour angiogenesis and metastasis. Since its …
Targeting HIF-1α by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression
FH Al-Ostoot, A Sherapura, VV, G Basappa… - Pharmacological …, 2021 - Springer
Background Hypoxic microenvironment is a common feature of solid tumors, which leads to
the promotion of cancer. The transcription factor, HIF-1α, expressed under hypoxic …
the promotion of cancer. The transcription factor, HIF-1α, expressed under hypoxic …
Cluster formation between an oxadiazole derivative with metal nanoclusters (Ag/Au/Cu), graphene quantum dot sheets, SERS studies, and solvent effects
Interaction of an oxadiazole derivative, 5-(3, 4-dimethoxyphenyl)-3-(3-methoxyphenyl)-1, 2,
4-oxadiazole (DPMO) with Ag/Au/Cu and graphene quantum dots with different solvents, is …
4-oxadiazole (DPMO) with Ag/Au/Cu and graphene quantum dots with different solvents, is …
A tumoural angiogenic gateway blocker, Benzophenone-1B represses the HIF-1α nuclear translocation and its target gene activation against neoplastic progression
Hypoxia is an important module in all solid tumours to promote angiogenesis, invasion and
metastasis. Stabilization and subsequent nuclear localization of HIF-1α subunits result in the …
metastasis. Stabilization and subsequent nuclear localization of HIF-1α subunits result in the …