Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …

Antibiotic resistance has become a global public health priority. Polymyxins, a family of
cationic polypeptide antibiotics, act as a final line of refuge against severe infections by …

Colistin represents one of the few available drugs for treating infections caused by
carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of …

Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …

Polymyxins have recently been re-introduced into the therapeutic arsenal to combat
infections caused by multidrug-resistant Gram-negative bacteria. However, the emergence …

The plasmid-located mcr-9 gene, encoding a putative phosphoethanolamine transferase,
was identified in a colistin-resistant human fecal Escherichia coli strain belonging to a very …

Polymyxins are important lipopeptide antibiotics that serve as the last-line defense against
multidrug-resistant (MDR) Gram-negative bacterial infections. Worryingly, the clinical utility …

In this Leading article, we summarize current knowledge of the occurrence of the first and so
far only transferable colistin resistance gene, mcr-1. Its location on a conjugative plasmid is …

Colistin and polymyxin B remain part of the last line of antibiotics for multidrug-resistant
Gram-negative bacteria, such as carbapenem-resistant Enterobacteriaceae. Current joint …

ABSTRACT A novel mcr variant, named mcr-1.2, encoding a Gln3-to-Leu functional variant
of MCR-1, was detected in a KPC-3-producing ST512 Klebsiella pneumoniae isolate …