Cervid prion protein polymorphisms: role in chronic wasting disease pathogenesis
MI Arifin, S Hannaoui, SC Chang, S Thapa… - International journal of …, 2021 - mdpi.com
Chronic wasting disease (CWD) is a prion disease found in both free-ranging and farmed
cervids. Susceptibility of these animals to CWD is governed by various exogenous and …
cervids. Susceptibility of these animals to CWD is governed by various exogenous and …
Emergence of CWD strains
A Otero, C Duque Velasquez, D McKenzie… - Cell and Tissue …, 2023 - Springer
Chronic wasting disease (CWD) strains present a novel challenge to defining and mitigating
this contagious prion disease of deer, elk, moose, and reindeer. Similar to strains of other …
this contagious prion disease of deer, elk, moose, and reindeer. Similar to strains of other …
[HTML][HTML] There is still time to reconcile forest management with climate-driven declines in habitat suitability for boreal caribou
M Leblond, Y Boulanger, JP Puigdevall… - Global Ecology and …, 2022 - Elsevier
Many boreal populations of woodland caribou in Canada are declining, mainly due to the
prevalence of anthropogenic disturbances which alter predator-prey dynamics. Climate …
prevalence of anthropogenic disturbances which alter predator-prey dynamics. Climate …
Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae
K Moazami-Goudarzi, O Andréoletti, JL Vilotte… - Veterinary …, 2021 - Springer
To date, chronic wasting disease (CWD) is the most infectious form of prion disease affecting
several captive, free ranging and wild cervid species. Responsible for marked population …
several captive, free ranging and wild cervid species. Responsible for marked population …
Effectiveness of population‐based recovery actions for threatened southern mountain caribou
Habitat loss is affecting many species, including the southern mountain caribou (Rangifer
tarandus caribou) population in western North America. Over the last half century, this …
tarandus caribou) population in western North America. Over the last half century, this …
Incorporating mechanism into conservation actions in an age of multiple and emerging threats: The case of boreal caribou
Conservation strategies for imperiled species are frequently based on identifying and
addressing the probable causes of population decline, an approach known as the declining …
addressing the probable causes of population decline, an approach known as the declining …
Heterozygosity for cervid S138N polymorphism results in subclinical CWD in gene-targeted mice and progressive inhibition of prion conversion
MI Arifin, L Kaczmarczyk, D Zeng… - Proceedings of the …, 2023 - National Acad Sciences
Prions are proteinaceous infectious particles that replicate by structural conversion of the
host-encoded cellular prion protein (PrPC), causing fatal neurodegenerative diseases in …
host-encoded cellular prion protein (PrPC), causing fatal neurodegenerative diseases in …
New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene
S Hannaoui, E Triscott, C Duque Velásquez… - PLoS …, 2021 - journals.plos.org
Chronic wasting disease (CWD) is a prion disease affecting cervids. Polymorphisms in the
prion protein gene can result in extended survival of CWD-infected animals. However, the …
prion protein gene can result in extended survival of CWD-infected animals. However, the …
Northern boreal caribou conservation should focus on anthropogenic disturbance, not disturbance-mediated apparent competition
Understanding the relative importance of threats to species across their range is critical for
large-scale conservation planning. Scaling-up localized research to inform the Canada-wide …
large-scale conservation planning. Scaling-up localized research to inform the Canada-wide …
Chronic wasting disease in Norway—a survey of prion protein gene variation among cervids
ME Güere, J Våge, H Tharaldsen… - Transboundary and …, 2022 - Wiley Online Library
Susceptibility of cervids to Chronic Wasting Disease (CWD), a prion disease, can be
modulated by variations in the prion protein gene (PRNP), encoding the cellular prion …
modulated by variations in the prion protein gene (PRNP), encoding the cellular prion …