Cervid prion protein polymorphisms: role in chronic wasting disease pathogenesis

MI Arifin, S Hannaoui, SC Chang, S Thapa… - International journal of …, 2021 - mdpi.com
Chronic wasting disease (CWD) is a prion disease found in both free-ranging and farmed
cervids. Susceptibility of these animals to CWD is governed by various exogenous and …

Emergence of CWD strains

A Otero, C Duque Velasquez, D McKenzie… - Cell and Tissue …, 2023 - Springer
Chronic wasting disease (CWD) strains present a novel challenge to defining and mitigating
this contagious prion disease of deer, elk, moose, and reindeer. Similar to strains of other …

[HTML][HTML] There is still time to reconcile forest management with climate-driven declines in habitat suitability for boreal caribou

M Leblond, Y Boulanger, JP Puigdevall… - Global Ecology and …, 2022 - Elsevier
Many boreal populations of woodland caribou in Canada are declining, mainly due to the
prevalence of anthropogenic disturbances which alter predator-prey dynamics. Climate …

Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae

K Moazami-Goudarzi, O Andréoletti, JL Vilotte… - Veterinary …, 2021 - Springer
To date, chronic wasting disease (CWD) is the most infectious form of prion disease affecting
several captive, free ranging and wild cervid species. Responsible for marked population …

Effectiveness of population‐based recovery actions for threatened southern mountain caribou

CT Lamb, S Williams, S Boutin, M Bridger… - Ecological …, 2024 - Wiley Online Library
Habitat loss is affecting many species, including the southern mountain caribou (Rangifer
tarandus caribou) population in western North America. Over the last half century, this …

Incorporating mechanism into conservation actions in an age of multiple and emerging threats: The case of boreal caribou

CA DeMars, CJ Johnson, M Dickie, TJ Habib… - …, 2023 - Wiley Online Library
Conservation strategies for imperiled species are frequently based on identifying and
addressing the probable causes of population decline, an approach known as the declining …

Heterozygosity for cervid S138N polymorphism results in subclinical CWD in gene-targeted mice and progressive inhibition of prion conversion

MI Arifin, L Kaczmarczyk, D Zeng… - Proceedings of the …, 2023 - National Acad Sciences
Prions are proteinaceous infectious particles that replicate by structural conversion of the
host-encoded cellular prion protein (PrPC), causing fatal neurodegenerative diseases in …

New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene

S Hannaoui, E Triscott, C Duque Velásquez… - PLoS …, 2021 - journals.plos.org
Chronic wasting disease (CWD) is a prion disease affecting cervids. Polymorphisms in the
prion protein gene can result in extended survival of CWD-infected animals. However, the …

Northern boreal caribou conservation should focus on anthropogenic disturbance, not disturbance-mediated apparent competition

C Superbie, KM Stewart, CE Regan, JF Johnstone… - Biological …, 2022 - Elsevier
Understanding the relative importance of threats to species across their range is critical for
large-scale conservation planning. Scaling-up localized research to inform the Canada-wide …

Chronic wasting disease in Norway—a survey of prion protein gene variation among cervids

ME Güere, J Våge, H Tharaldsen… - Transboundary and …, 2022 - Wiley Online Library
Susceptibility of cervids to Chronic Wasting Disease (CWD), a prion disease, can be
modulated by variations in the prion protein gene (PRNP), encoding the cellular prion …