Penicillin-binding proteins (PBPs) have been scrutinized for over 40 years. Recent structural
information on PBPs together with the ongoing long-term biochemical experimental …

The simplistic image of the bacterium as an isolated, planktonic, self-cloning automaton is
refuted. We now recognize bacteria as microorganisms of enormous diversity and …

Drug platforms that enable the directed delivery of therapeutics to sites of diseases to
maximize efficacy and limit off-target effects are needed. Here, we report the development of …

Corynebacterium glutamicum is an important organism for the industrial production of amino
acids. Metabolic pathways in this organism are usually engineered by conventional methods …

In order to maintain shape and withstand intracellular pressure, most bacteria are
surrounded by a cell wall that consists mainly of the cross-linked polymer peptidoglycan …

Work on two diverse rod-shaped bacteria, Escherichia coli and Bacillus subtilis, has defined
a set of about 10 conserved proteins that are important for cell division in a wide range of …

The cytokinetic Z ring is required for bacterial cell division. It consists of polymers of FtsZ, the
bacterial ancestor of eukaryotic tubulin, linked to the cytoplasmic membrane. Formation of a …

ZipA and FtsA are essential division proteins in Escherichia coli that are recruited to the
division site by interaction with FtsZ. Utilizing a newly isolated temperature‐sensitive …

Despite the need for new antibiotics to treat drug-resistant bacteria, current clinical
combinations are largely restricted to β-lactam antibiotics paired with β-lactamase inhibitors …

At the heart of bacterial cell division is a dynamic ring-like structure of polymers of the tubulin
homologue FtsZ. This ring forms a scaffold for assembly of at least ten additional proteins at …