RNA recognition motifs: boring? Not quite
The RNA recognition motif (RRM) is one of the most abundant protein domains in
eukaryotes. While the structure of this domain is well characterized by the packing of two α …
eukaryotes. While the structure of this domain is well characterized by the packing of two α …
The life of U6 small nuclear RNA, from cradle to grave
AL Didychuk, SE Butcher, DA Brow - Rna, 2018 - rnajournal.cshlp.org
Removal of introns from precursor messenger RNA (pre-mRNA) and some noncoding
transcripts is an essential step in eukaryotic gene expression. In the nucleus, this process of …
transcripts is an essential step in eukaryotic gene expression. In the nucleus, this process of …
One, two, three, four! How multiple RRMs read the genome sequence
RRM-containing proteins are involved in most of the RNA metabolism steps. Their functions
are closely related to their mode of RNA recognition, which has been studied by structural …
are closely related to their mode of RNA recognition, which has been studied by structural …
Structures, kinetics, thermodynamics, and biological functions of RNA hairpins
PC Bevilacqua, JM Blose - Annu. Rev. Phys. Chem., 2008 - annualreviews.org
Most RNA comprises one strand and therefore can fold back on itself to form complex
structures. At the heart of these structures is the hairpin, which is composed of a stem having …
structures. At the heart of these structures is the hairpin, which is composed of a stem having …
A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins
Cytoplasmic changes in polyA tail length is a key mechanism of translational control and is
implicated in germline development, synaptic plasticity, cellular proliferation, senescence …
implicated in germline development, synaptic plasticity, cellular proliferation, senescence …
Taming free energy landscapes with RNA chaperones
SA Woodson - RNA biology, 2010 - Taylor & Francis
Many non-coding RNAs fold into complex three-dimensional structures, yet the self-
assembly of RNA structure is hampered by mispairing, weak tertiary interactions …
assembly of RNA structure is hampered by mispairing, weak tertiary interactions …
Structure and function of the Pre-mRNA splicing machine
J Sperling, M Azubel, R Sperling - Structure, 2008 - cell.com
Most eukaryotic pre-mRNAs contain non-coding sequences (introns) that must be removed
in order to accurately place the coding sequences (exons) in the correct reading frame. This …
in order to accurately place the coding sequences (exons) in the correct reading frame. This …
Core structure of the U6 small nuclear ribonucleoprotein at 1.7-Å resolution
EJ Montemayor, EC Curran, HH Liao… - Nature structural & …, 2014 - nature.com
The spliceosome is a dynamic assembly of five small nuclear ribonucleoproteins (snRNPs)
that removes introns from eukaryotic pre-mRNA. U6, the most conserved of the spliceosomal …
that removes introns from eukaryotic pre-mRNA. U6, the most conserved of the spliceosomal …
Solution structure of the two RNA recognition motifs of hnRNP A1 using segmental isotope labeling: how the relative orientation between RRMs influences the nucleic …
P Barraud, FHT Allain - Journal of biomolecular NMR, 2013 - Springer
Human hnRNP A1 is a multi-functional protein involved in many aspects of nucleic-acid
processing such as alternative splicing, micro-RNA biogenesis, nucleo-cytoplasmic mRNA …
processing such as alternative splicing, micro-RNA biogenesis, nucleo-cytoplasmic mRNA …
Alopecia, neurological defects, and endocrinopathy syndrome caused by decreased expression of RBM28, a nucleolar protein associated with ribosome biogenesis
J Nousbeck, R Spiegel, A Ishida-Yamamoto… - The American Journal of …, 2008 - cell.com
Single-gene disorders offer unique opportunities to shed light upon fundamental
physiological processes in humans. We investigated an autosomal-recessive phenotype …
physiological processes in humans. We investigated an autosomal-recessive phenotype …