Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …

As angiogenesis was recognized as a core hallmark of cancer growth and survival, several
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …

It is highly desirable to turn" cold" tumors into" hot" ones to improve the efficacy of antitumor
immunotherapy. Herein, we develop the peptide-based small interfering RNA (siRNA) …

The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence
have been recognized for many decades. Due to their strong capacity for self-renewal and …

High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte
trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high …

The lack of sufficient intratumoral CD8+ T lymphocytes is a significant obstacle to effective
immunotherapy in cancer. High endothelial venules (HEVs) are organ-specific and …

High endothelial venules (HEVs) are specialized postcapillary venules composed of
cuboidal blood endothelial cells that express high levels of sulfated sialomucins to bind L …

Background & Aims Hepatocellular carcinoma (HCC) is among the most prevalent and
lethal cancers worldwide. The tumor microenvironment (TME) contributes to the poor …

The infiltration of cytotoxic T lymphocytes (CTLs) in tumors is critically challenged by the
intricate intratumor physical barriers, which is emerging as an important issue of anticancer …

Immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment. However,
only a fraction of patients respond to ICB therapy. Accurate prediction of patients to likely …