Cardiac myosin contraction and mechanotransduction in health and disease
SK Barrick, MJ Greenberg - Journal of Biological Chemistry, 2021 - ASBMB
Cardiac myosin is the molecular motor that powers heart contraction by converting chemical
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …
Complexity in genetic cardiomyopathies and new approaches for mechanism-based precision medicine
MJ Greenberg, JC Tardiff - Journal of General Physiology, 2021 - rupress.org
Genetic cardiomyopathies have been studied for decades, and it has become increasingly
clear that these progressive diseases are more complex than originally thought. These …
clear that these progressive diseases are more complex than originally thought. These …
A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle
RF Kawas, RL Anderson, SRB Ingle, Y Song… - Journal of Biological …, 2017 - ASBMB
Mavacamten, formerly known as MYK-461 is a recently discovered novel small-molecule
modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of …
modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of …
Adhesion strength and contractility enable metastatic cells to become adurotactic
Significant changes in cell stiffness, contractility, and adhesion, ie, mechanotype, are
observed during a variety of biological processes. Whether cell mechanics merely change …
observed during a variety of biological processes. Whether cell mechanics merely change …
Omecamtiv mecarbil enhances the duty ratio of human β-cardiac myosin resulting in increased calcium sensitivity and slowed force development in cardiac muscle
AM Swenson, W Tang, CA Blair, CM Fetrow… - Journal of Biological …, 2017 - ASBMB
The small molecule drug omecamtiv mecarbil (OM) specifically targets cardiac muscle
myosin and is known to enhance cardiac muscle performance, yet its impact on human …
myosin and is known to enhance cardiac muscle performance, yet its impact on human …
Velocity of myosin-based actin sliding depends on attachment and detachment kinetics and reaches a maximum when myosin-binding sites on actin saturate
Molecular motors such as kinesin and myosin often work in groups to generate the directed
movements and forces critical for many biological processes. Although much is known about …
movements and forces critical for many biological processes. Although much is known about …
A perspective on the role of myosins as mechanosensors
Cells are dynamic systems that generate and respond to forces over a range of spatial and
temporal scales, spanning from single molecules to tissues. Substantial progress has been …
temporal scales, spanning from single molecules to tissues. Substantial progress has been …
Bipolar filaments of human nonmuscle myosin 2-A and 2-B have distinct motile and mechanical properties
Nonmusclemyosin 2 (NM-2) powers cell motility and tissue morphogenesis by assembling
into bipolar filaments that interact with actin. Although the enzymatic properties of purified …
into bipolar filaments that interact with actin. Although the enzymatic properties of purified …
Coupling of retrograde flow to force production during malaria parasite migration
KA Quadt, M Streichfuss, CA Moreau, JP Spatz… - ACS …, 2016 - ACS Publications
Migration of malaria parasites is powered by a myosin motor that moves actin filaments,
which in turn link to adhesive proteins spanning the plasma membrane. The retrograde flow …
which in turn link to adhesive proteins spanning the plasma membrane. The retrograde flow …
Blebbistatin effects expose hidden secrets in the force-generating cycle of actin and myosin
Cyclic interactions between myosin II motors and actin filaments driven by ATP turnover
underlie muscle contraction and have key roles in the motility of nonmuscle cells. A …
underlie muscle contraction and have key roles in the motility of nonmuscle cells. A …