The microbiome plays an important role in a wide variety of skin disorders. Not only is the
skin microbiome altered, but also surprisingly many skin diseases are accompanied by an …

The use of preclinical animal models of psoriasis has significantly increased over the last
three decades, with each model having unique strengths and limitations. Some models …

Psoriasis is a complex disease triggered by genetic, immunologic, and environmental
stimuli. Many genes have been linked to psoriasis, like the psoriasis susceptibility genes …

TNF and IL-17 are two cytokines that drive dysregulated keratinocyte activity, and their
targeting is highly efficacious in patients with psoriasis, but whether these molecules act with …

Since 2009, the imiquimod-or Aldara-induced (3M Pharmaceuticals, St. Paul, MN) model of
acute skin inflammation has become the most widely used mouse model in preclinical …

Psoriasis has long been associated with inflammatory bowel disease (IBD); however, a
causal link is yet to be established. Here, we demonstrate that imiquimod-induced psoriasis …

Introduction: Psoriasis is an autoimmune skin disease characterized by red plaques with
silver or white multilayered scales with a thickened acanthotic epidermis. Using mouse …

Psoriasis vulgaris is a common, inflammatory skin disease affecting approximately 3% of the
population in the United States. The etiology of psoriasis and its associated comorbidities …

Psoriasis is a common immune‐mediated chronic inflammatory skin disease characterized
by thick and erythema raised plaques with adherent silvery scales. T‐cells are activated via …

Recently, the mTOR signaling has emerged as an important player in the pathogenesis of
psoriasis. We previously found that 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced …