Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly
regarded as being in the early stages of a progressive neurodegenerative disease involving …

So-called idiopathic rapid eye movement (REM) sleep behaviour disorder (RBD), formerly
seen as a rare parasomnia, is now recognized as the prodromal stage of an α …

Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson's
disease, dementia with Lewy bodies, and multiple system atrophy. This provides an …

Several studies have confirmed the α-synuclein real-time quaking-induced conversion (RT-
QuIC) assay to have high sensitivity and specificity for Parkinson's disease. However …

Braak's hypothesis has been extremely influential over the last two decades. However,
neuropathological and clinical evidence suggest that the model does not conform to all …

Background Studies regarding the impact of Parkinson's disease (PD) on quality of life
(QOL) have reported conflicting results, and the underlying QOL domains require further …

A new model of Parkinson's disease (PD) pathogenesis is proposed, the α-Synuclein Origin
site and Connectome (SOC) model, incorporating two aspects of α-synuclein pathobiology …

Parkinson's disease (PD) is the second most common degenerative disorder. Although the
disease was described more than 200 years ago, its pathogenetic mechanisms have not yet …

Background The literature regarding clinical olfaction, olfactory loss, and olfactory
dysfunction has expanded rapidly over the past two decades, with an exponential rise in the …

Several studies report an association between REM Sleep Behavior Disorder (RBD) and
neurodegenerative diseases, in particular synucleinopathies. Interestingly, the onset of RBD …