The number of cases of severe dengue disease continues to grow in endemic areas of
southeast Asia, Central and South America, and other subtropical regions. Children bear the …

Genus flavivirus comprises many important human pathogens causing public health
problems worldwide. Some flavivirus infections are characterized by a relatively high …

Background Dengue virus is the most serious mosquito-borne viral threat to public health
and no vaccines or antiviral therapies are approved for dengue fever. The tetravalent …

Dengue virus is the most widespread geographically of the arboviruses and a major public
health threat in the tropics and subtropics. Scientific advances in recent years have provided …

Dengue. virus infection is the leading arboviral cause of disease worldwide. A vaccine is
being developed based on the attenuated DEN-2 virus, DEN-2 PDK-53. In this review, we …

Abstract Background. Sanofi Pasteur has developed a tetravalent dengue vaccine (TDV)
against the world's most common arbovirus infection. Methods. We assessed the safety and …

Challenges associated with the interference observed between the dengue virus
components within early tetravalent live-attenuated vaccines led many groups to explore the …

A recombinant live attenuated tetravalent dengue vaccine (TDV) is safe and immunogenic in
adults and children in dengue-naïve populations. Data are needed in dengue endemic …

Dengue Virus (DENV) is an arbovirus (arthropod-borne virus). Four serotypes of DENV are
responsible for the infectious disease called dengue that annually affects nearly 400 million …

With several dengue vaccine candidates progressing through clinical trials, several options
for controlling this disease appear feasible. This would represent a major achievement and …