A review on gout: Looking back and looking ahead
Gout is a metabolic disease caused by the deposition of monosodium urate (MSU) crystals
inside joints, which leads to inflammation and tissue damage. Increased concentration of …
inside joints, which leads to inflammation and tissue damage. Increased concentration of …
TET2-mutant clonal hematopoiesis and risk of gout
Gout is a common inflammatory arthritis caused by precipitation of monosodium urate (MSU)
crystals in individuals with hyperuricemia. Acute flares are accompanied by secretion of …
crystals in individuals with hyperuricemia. Acute flares are accompanied by secretion of …
Pathophysiological role and potential drug target of NLRP3 inflammasome in the metabolic disorders
H Hu, S Wang, C Chen - Cellular Signalling, 2024 - Elsevier
NLRP3 plays a role in the development of autoinflammatory diseases. NLRP3, ASC, and
Caspases 1 or 8 make up the NLRP3 inflammasome, which is an important part of innate …
Caspases 1 or 8 make up the NLRP3 inflammasome, which is an important part of innate …
[HTML][HTML] Folic acid-modified lysozyme protected gold nanoclusters as an effective anti-inflammatory drug for rapid relief of gout flares in hyperuricemic rats
J Sun, P Zhuang, S Wen, M Ge, Z Zhou, D Li, C Liu… - Materials & Design, 2022 - Elsevier
Background Gout normally occurs when excess urate crystals accumulate in the joints that
induce inflammation. The inflammations further result in gout flares, causing serious pain …
induce inflammation. The inflammations further result in gout flares, causing serious pain …
[HTML][HTML] Association between the dietary inflammatory index and gout in the National Health and Nutrition Examination Survey 2007–2018
Y Zhang, J Song, Y Lai, A Li, Y Zhang, H Zhou, W Zhao… - Heliyon, 2023 - cell.com
Objective The aim of our study was to investigate whether the Dietary Inflammatory Index
(DII) correlated with gout in American adults. Method The study used data from the 2007 …
(DII) correlated with gout in American adults. Method The study used data from the 2007 …
A stable liver-specific urate oxidase gene knockout hyperuricemia mouse model finds activated hepatic de novo purine biosynthesis and urate nephropathy
L Pang, N Liang, C Li, TR Merriman, H Zhang… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Urate oxidase (Uox)-deficient mice could be an optimal animal model to study
hyperuricemia and associated disorders. We develop a liver-specific conditional knockout …
hyperuricemia and associated disorders. We develop a liver-specific conditional knockout …
Dual-Energy Computed Tomography Applications in Rheumatology
EH Park, T O'Donnell, J Fritz - Radiologic Clinics, 2024 - radiologic.theclinics.com
Rheumatic diseases are associated with significant disability, loss of productivity, and
reduction in quality of life, resulting in substantial impacts on individuals and society …
reduction in quality of life, resulting in substantial impacts on individuals and society …
Structure-activity relationships of natural and synthetic lathyrane-based diterpenoids for suppression of NLRP3-driven inflammation and gouty arthritis
Y Zhuang, B Pan, Y Zhang, Z Tang, X Ji, S Zhang… - Bioorganic …, 2024 - Elsevier
Lathyrane-based diterpenoid is one of the critical bioactive elements of Euphorbia lathyris
L., a widely used traditional Chinese medicine for the treatment of inflammation and …
L., a widely used traditional Chinese medicine for the treatment of inflammation and …
Efficacy and safety of Huzhang Granule, a compound Chinese herbal medicine, for acute gouty arthritis: A double-blind, randomized controlled trial
H Wang, S Chen, X Ding, L Kuai, L Hua, X Li… - Journal of Integrative …, 2024 - Elsevier
Background Acute gouty arthritis (AGA) is an inflammatory joint disease with a high
prevalence. Typical medical interventions, including nonsteroidal anti-inflammatory drugs …
prevalence. Typical medical interventions, including nonsteroidal anti-inflammatory drugs …