Clonal hematopoiesis of indeterminate potential predicts adverse outcomes in patients with atherosclerotic cardiovascular disease
Background Clonal hematopoiesis of indeterminate potential (CHIP)—the age-related clonal
expansion of blood stem cells with leukemia-associated mutations—is a novel …
expansion of blood stem cells with leukemia-associated mutations—is a novel …
Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations
YA Jakubek, AP Reiner, MC Honigberg - Translational Research, 2023 - Elsevier
Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal
alterations (mCAs) of the autosomes, X, and Y chromosomes are aging-related somatic …
alterations (mCAs) of the autosomes, X, and Y chromosomes are aging-related somatic …
Genetic variation across and within individuals
Germline variation and somatic mutation are intricately connected and together shape
human traits and disease risks. Germline variants are present from conception, but they vary …
human traits and disease risks. Germline variants are present from conception, but they vary …
Inherited polygenic effects on common hematological traits influence clonal selection on JAK2V617F and the development of myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) are chronic cancers characterized by overproduction
of mature blood cells. Their causative somatic mutations, for example, JAK2 V617F, are …
of mature blood cells. Their causative somatic mutations, for example, JAK2 V617F, are …
Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis
Clonal hematopoiesis of indeterminate potential (CHIP) is linked to diverse aging-related
diseases, including hematologic malignancy and atherosclerotic cardiovascular disease …
diseases, including hematologic malignancy and atherosclerotic cardiovascular disease …
Birth weight is associated with clonal hematopoiesis of indeterminate potential and cardiovascular outcomes in adulthood
Background High and low birth weight are independently associated with increased
cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential …
cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential …
Germline predisposition to clonal hematopoiesis
We now recognize that with aging, hematopoietic stem and progenitor cells (HSPCs)
acquire mutations that confer a fitness advantage and clonally expand in a process now …
acquire mutations that confer a fitness advantage and clonally expand in a process now …
Germline Predisposition in Hematologic Malignancies: Testing, Management, and Implications
LA Godley, CD DiNardo, K Bolton - American Society of Clinical …, 2024 - ascopubs.org
Although numerous barriers for clinical germline cancer predisposition testing exist, the
increasing recognition of deleterious germline DNA variants contributing to myeloid …
increasing recognition of deleterious germline DNA variants contributing to myeloid …
[HTML][HTML] Long-term longitudinal analysis of 4,187 participants reveals new insights into determinants of incident clonal hematopoiesis
MM Uddin, S Saadatagah, A Niroula, B Yu, W Hornsby… - medRxiv, 2023 - ncbi.nlm.nih.gov
Clonal hematopoiesis (CH), characterized by blood cells predominantly originating from a
single mutated hematopoietic stem cell, is linked to diverse aging-related diseases …
single mutated hematopoietic stem cell, is linked to diverse aging-related diseases …
[HTML][HTML] Prevalence and therapeutic implications of clonal hematopoiesis of indeterminate potential in young patients with stroke
Background: Undetermined stroke etiology hampers optimal secondary prevention in a
large proportion of young patients. We explored whether genetic screening for clonal …
large proportion of young patients. We explored whether genetic screening for clonal …