Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Nitroxides can undergo one-or two-electron reduction reactions to hydroxylamines or
oxammonium cations, respectively, which themselves are interconvertible, thereby providing …

In the kidney nitric oxide (NO) has numerous important functions including the regulation of
renal haemodynamics, maintenance of medullary perfusion, mediation of pressure …

Adequate 24-h BP control presently offers the most feasible intervention for reducing
glomerular BP transmission and improving suboptimal outcomes in CKD. Investigations …

Loss of redox homeostasis and formation of excessive free radicals play an important role in
the pathogenesis of kidney disease and hypertension. Free radicals such as reactive …

Endothelial dysfunction in ischemic acute renal failure (IARF) has been attributed to both
direct endothelial injury and to altered endothelial nitric oxide synthase (eNOS) activity, with …

Background and aims Hypertension is a major risk factor for chronic kidney disease (CKD),
and CKD progression is associated with suboptimal blood pressure (BP) control. Here we …

Chronic ANG II infusion in rodents is widely used as an experimental model of hypertension,
yet very limited data are available describing the resulting blood pressure-renal blood flow …

Hypertensive vascular disorders are characterized by endothelial dysfunction. Loss of renal
autoregulation causes glomerular hypertension. However, the relationship between the …

To assess the role of superoxide (O2−) and nitric oxide (NO) interaction in mediating the
renal actions of ANG II, we examined the renal responses to intra-arterial infusion of ANG II …