The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once
disrupted, it can lead to various pathological outcomes and diseases, such as depression …

Rationale Depression has the topmost prevalence of all psychiatric diseases. It is
characterized by a high recurrence rate, disability, and numerous and mostly unclear …

Pyroptosis is a form of cell death triggered by the innate immune system that has been
implicated in the pathogenesis of sepsis and acute lung injury. At the cellular level …

In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …

Background Selective serotonin reuptaker inhibitors, including fluoxetine, are widely studied
and prescribed antidepressants, while their exact molecular and cellular mechanism are yet …

Background Renal interstitial fibrosis (RIF) is one of the main features of diabetic
nephropathy (DN), but the molecular mechanisms mediating RIF in DN has yet been fully …

Quercetin is a flavonoid compound rich in many natural plants with a wide range of
pharmacological effects and nutritional value. Although previous studies have initially shown …

Depression is a risk factor for Alzheimer's (AD) and cardiovascular diseases (CVD).
Therefore, depression treatment restricts its deteriorating effects on mood, memory and CV …

Abstract Ethnopharmacological relevance Neuroprotective Traditional Chinese Medicine
(TCM) has been practiced in alternative medicine from early days. TCM-derived …

Methamphetamine (METH) leads to nervous system toxicity. Long‐term exposure to METH
results in damage to dopamine neurons in the ventral tegmental area (VTA), and depression …