Non-canonical roles of telomerase: unraveling the imbroglio

E Ségal-Bendirdjian, V Geli - Frontiers in Cell and Developmental …, 2019 - frontiersin.org
Telomerase plays a critical role in stem cell function and tissue regeneration that depends
on its ability to elongate telomeres. For nearly two decades, it turned out that TERT regulates …

Stress and immunosenescence: The role of telomerase

K de Punder, C Heim, PD Wadhwa… - Psychoneuroendocrinology, 2019 - Elsevier
Chronic stress is associated with the accelerated aging of the immune system and
represents a potent risk factor for the development and progression of a wide range of …

Improving the effectiveness of anti-aging modalities by using the constrained disorder principle-based management algorithms

N Hurvitz, N Elkhateeb, T Sigawi, L Rinsky-Halivni… - Frontiers in …, 2022 - frontiersin.org
Aging is a complex biological process with multifactorial nature underlined by genetic,
environmental, and social factors. In the present paper, we review several mechanisms of …

Critical role for telomerase in the mechanism of flow-mediated dilation in the human microcirculation

AM Beyer, JK Freed, MJ Durand, M Riedel… - Circulation …, 2016 - Am Heart Assoc
Rationale: Telomerase is a nuclear regulator of telomere elongation with recent reports
suggesting a role in regulation of mitochondrial reactive oxygen species. Flow-mediated …

Telomere length maintenance and cardio-metabolic disease prevention through exercise training

J Denham, BJ O'Brien, FJ Charchar - Sports medicine, 2016 - Springer
Telomeres are tandem repeat DNA sequences located at distal ends of chromosomes that
protect against genomic DNA degradation and chromosomal instability. Excessive telomere …

Deciphering the impact of TERT/telomerase on immunosenescence and T cell revitalization

L Huang, M Zhang, D Bai, Y Qu - Frontiers in Immunology, 2024 - frontiersin.org
Immunosenescence impacts both the innate and adaptive immune systems, predominantly
affecting certain immune cell types. A notable manifestation of immunosenescence is the …

Magnesium and the Hallmarks of Aging

LJ Dominguez, N Veronese, M Barbagallo - Nutrients, 2024 - mdpi.com
Magnesium is an essential ion in the human body that regulates numerous physiological
and pathological processes. Magnesium deficiency is very common in old age. Age-related …

miR-346 and miR-138 competitively regulate hTERT in GRSF1-and AGO2-dependent manners, respectively

G Song, R Wang, J Guo, X Liu, F Wang, Y Qi, H Wan… - Scientific reports, 2015 - nature.com
Abstract miRNAs typically downregulate the expression of target genes by binding to their
3′ UTR and dysregulation of miRNAs may contribute to tumorigenesis. Here, we found that …

Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway

ST Wang, SW Huang, KT Liu, TY Lee, JJ Shieh… - Cell death …, 2020 - nature.com
Hepatocellular carcinoma (HCC), a hepatic malignancy, has a poor prognosis and
contributes to cancer-related death worldwide. Cellular senescence is an anticancer …

Telomerase increasing compound protects hippocampal neurons from amyloid beta toxicity by enhancing the expression of neurotrophins and plasticity related genes

N Baruch-Eliyahu, V Rud, A Braiman, E Priel - Scientific reports, 2019 - nature.com
The telomerase reverse transcriptase protein, TERT, is expressed in the adult brain and its
exogenic expression protects neurons from oxidative stress and from the cytotoxicity of …