Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide and is
predicted to become second in 2030 in industrialized countries if no therapeutic progress is …

ADAM9 (A disintegrin and a metalloprotease 9) is a membrane-anchored protein that
participates in a variety of physiological functions, primarily through the disintegrin domain …

Background Although mRNA vaccines have been effective against multiple cancers, their
efficacy against pancreatic adenocarcinoma (PAAD) remains undefined. Accumulating …

Numerous software tools exist for data-independent acquisition (DIA) analysis of clinical
samples, necessitating their comprehensive benchmarking. We present a benchmark …

Circular RNAs (circRNAs) is a class of non-coding RNA with important functions in tumor
development and progression. In the previous study, circ_0020123 was found to be an …

Pancreatic ductal adenocarcinoma (PDAC) represents one of the most aggressive and
lethal malignancies worldwide with an urgent need for new diagnostic and therapeutic …

Platelets have been recognized as key players in hemostasis, thrombosis, and cancer.
Preclinical and clinical researches evidenced that tumorigenesis and metastasis can be …

Metalloproteinases cleave transmembrane proteins that play critical roles in inflammation
and cancers. Metalloproteinases include a disintegrin and metalloprotease (ADAM), which …

ADAM proteases are multi domain transmembrane metalloproteases that cleave a range of
cell surface proteins and activate signaling pathways implicated in tumor progression …

Kirsten rat sarcoma virus (KRAS) signaling drives pancreatic ductal adenocarcinoma
(PDAC) malignancy, which is an unmet clinical need. Here, we identify a disintegrin and …