Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders with
notable factor of dysfunction in cholinergic system. Low ACh level can be observed in the …

This article emphasizes on the importance of benzofuran as a biologically relevant
heterocycle. It covers most of the physiologically as well as medicinally important …

We report that fullerene inhibits strongly the amyloid peptide aggregation at the early stage.
It specifically binds to the central hydrophobic motif, KLVFF, of Aβ peptides. The IC50 value …

Twenty-six new tacrine–benzofuran hybrids were designed, synthesized, and evaluated in
vitro on key molecular targets for Alzheimer's disease. Most hybrids exhibited good inhibitory …

This chapter provides an overview of literature from 1996 on the applications of various
furan and benzofuran containing compounds. In addition to compounds that contain a furan …

Alzheimer's disease is a neurodegenerative disorder that is the leading cause of dementia
in elderly patients. Amyloid-β peptide (1–42 oligomers) has been identified as a neurotoxic …

Alzheimer's disease (AD) is a neurodegenerative disorder, which is complex and
progressive; it has not only threatened the health of elderly people, but also burdened the …

The ability of galantamine (Reminyl®) to inhibit the aggregation and toxicity of the β-amyloid
peptide (Aβ) was investigated. Galantamine showed concentration-dependent inhibition of …

Background: The design of multifunctional agents represents one of the most active
research field in medicinal chemistry. In particular, tacrine, a well known …

The first synthesis of 4-, 5-, and 6-nitrobenzo [b] furans has been achieved via the
Sonogashira cross-coupling reaction of 2-iodonitrophenol acetates prepared from …