Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy

Y Cao, X Wang, T Jin, Y Tian, C Dai… - Signal transduction and …, 2020 - nature.com
Recent studies have demonstrated the potential of natural killer (NK) cells in immunotherapy
to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles …

Oncogenic effects of HIV-1 proteins, mechanisms behind

M Isaguliants, E Bayurova, D Avdoshina… - Cancers, 2021 - mdpi.com
Simple Summary People living with human immunodeficiency virus type 1 (HIV-1)(PLWH)
are at increased risk of developing cancer despite successful antiretroviral therapy (ART) …

[HTML][HTML] Utilization of immunological ratios in HIV: Implications for monitoring and therapeutic strategies

EI Obeagu, GU Obeagu - Medicine, 2024 - journals.lww.com
Human immunodeficiency virus (HIV) infection remains a significant global health concern,
necessitating ongoing research and innovation in the quest for improved disease …

Myeloid cells during viral infections and inflammation

AA Stegelmeier, JP van Vloten, RC Mould, EM Klafuric… - Viruses, 2019 - mdpi.com
Myeloid cells represent a diverse range of innate leukocytes that are crucial for mounting
successful immune responses against viruses. These cells are responsible for detecting …

KLRG1 expression on natural killer cells is associated with HIV persistence, and its targeting promotes the reduction of the viral reservoir

A Astorga-Gamaza, D Perea, N Sanchez-Gaona… - Cell Reports …, 2023 - cell.com
Human immunodeficiency virus (HIV) infection induces immunological dysfunction, which
limits the elimination of HIV-infected cells during treated infection. Identifying and targeting …

Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients

L Yan, K Xu, Q Xiao, L Tuo, T Luo, S Wang… - Frontiers in …, 2023 - frontiersin.org
Highly active antiretroviral therapy (ART) can effectively inhibit virus replication and restore
immune function in most people living with human immunodeficiency virus (HIV). However …

Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a Mycobacterium tuberculosis/SIV coinfection model

R Sharan, SR Ganatra, AN Bucsan… - The Journal of …, 2022 - Am Soc Clin Investig
Studies using the nonhuman primate model of Mycobacterium tuberculosis/simian
immunodeficiency virus coinfection have revealed protective CD4+ T cell–independent …

Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution …

PS Silveira-Mattos, G Narendran, K Akrami… - Scientific reports, 2019 - nature.com
Immune reconstitution inflammatory syndrome (IRIS) occurs in up to 40% of individuals co-
infected with pulmonary tuberculosis (PTB) and HIV, primarily upon antiretroviral therapy …

NK cells from Men Who Have Sex with Men at high risk for HIV-1 infection exhibit higher effector capacity

DS Rincón, L Flórez-Álvarez, NA Taborda… - Scientific Reports, 2023 - nature.com
Despite being under constant exposure to HIV-1, some individuals do not show serological
or clinical evidence of infection and are known as HESN (HIV-Exposed Seronegative) …

Innate and adaptive abnormalities in youth with vertically acquired HIV through a multicentre cohort in Spain

I Carrasco, L Tarancon‐Diez… - African Journal of …, 2021 - journals.lww.com
Introduction: Immune abnormalities have been described among youth with vertically
acquired HIV (YWVH) despite antiretroviral treatment (ART). The CD4/CD8 ratio could be a …