Making sense of rapidly evolving evidence on genetic associations is crucial to making
genuine advances in human genomics and the eventual integration of this information in the …

The cytochrome P450 3A (CYP3A) subfamily members are the most abundant and important
drug-metabolizing enzymes in humans, and wide interindividual variability in CYP3A …

Population stratification refers to differences in allele frequencies between cases and
controls due to systematic differences in ancestry rather than association of genes with …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on
chromosome 8q24 as significantly associated with susceptibility to prostate cancer …

Ancestry informative markers (AIMs) are genetic loci showing alleles with large frequency
differences between populations. AIMs can be used to estimate biogeographical ancestry at …

To control for hidden population stratification in genetic-association studies, statistical
methods that use marker genotype data to infer population structure have been proposed as …

Much of P450 research has always been done with the view of appUcation to humans, even
when done with experimental animals and microorganisms. Research with the human …

Admixture mapping (also known as" mapping by admixture linkage disequilibrium," or
MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups …

Human cytochrome P450 (CYP) enzymes play a key role in the metabolism of drugs and
environmental chemicals. Several CYP enzymes metabolically activate procarcinogens to …