Autophagy, originally found in liver experiments, is a cellular process that degrades
damaged organelle or protein aggregation. This process frees cells from various stress …

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy and nutrient status,
expressed almost universally in eukaryotes as heterotrimeric complexes comprising catalytic …

Resveratrol has emerged in recent years as a compound conferring strong protection
against metabolic, cardiovascular and other age-related complications, including …

Type 2 diabetes (T2D) is a metabolic disease characterized by insulin resistance, β-cell
dysfunction, and elevated hepatic glucose output. Over 350 million people worldwide have …

Background and Purpose The growing epidemic of obesity and metabolic diseases
necessitates the development of novel strategies to prevent and treat such diseases. Current …

In obesity and type 2 diabetes, Glut4 glucose transporter expression is decreased
selectively in adipocytes. Adipose-specific knockout or overexpression of Glut4 alters …

AMP-activated protein kinase (AMPK) has a major role in the modulation of energy balance.
AMPK is activated in conditions of low energy, increasing energy production and reducing …

Maintenance of body temperature is essential for the survival of homeotherms. Brown
adipose tissue (BAT) is a specialized fat tissue that is dedicated to thermoregulation. Owing …

AMP-activated protein kinase (AMPK) is a critical regulator of cellular metabolism and plays
an important role in diabetes, cancer, and vascular disease. In the heart, AMPK activation is …

AMPK (AMP-activated protein kinase) is a key regulator of cellular and whole-body energy
balance. AMPK phosphorylates and regulates many proteins concerned with nutrient …